CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16109
Family Name Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha and Protein farnesyltransferase subunit beta inhibitor N-cyano-4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]-N'-[(1-oxidopyridin-1-ium-3-yl)methyl]piperidine-1-carboximidamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00437038 Functional Category Bioactive
Superfamily Farnesyltransferase beta subunit, putative Inhibitor Lonafarnib Superfamily
Class Class 891

Cousin Family NamesSeedsMembers
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Farnesyltransferase beta subunit, putative Inhibitor Lonafarni... 36 87
Somatostatin receptor type 4 and Glucosylceramidase ligand MLS... 1 16
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 10 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00437038 CHEMBL348647 Bioactive N-cyano-4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]-N'-[(1-oxidopyridin-1-ium-3-yl)methyl]piperidine-1-carboximidamide
CFAMM00437039 CHEMBL352022 Bioactive AGN-PC-075UAO

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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