CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1613
Family Name Sigma non-opioid intracellular receptor 1 and 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase ligand 1-[(2S)-3-(4-chlorophenoxy)-2-methylpropyl]-4-methylpiperidine;hydrochloride family
No. of Seeds 15 No. of Other Members 11
Family Centroid CFAMM00153739 Functional Category Bioactive
Superfamily Sigma non-opioid intracellular receptor 1 and Histamine H3 receptor Binder Superfamily
Class Class 3413

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Amine oxidase [flavin-containing] A Inhibitor Clorgyline Family 3 6
Leukotriene A-4 hydrolase Inhibitor DG051 Family 2 8
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Dipeptidyl peptidase 4 Inhibitor (2-chloro-6-phenoxyphenyl)met... 17 24
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
Histamine H3 receptor Ligand 1-(3-(2-(3-methoxyphenoxy)ethoxy)... 3 9
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Inhibitor 2... 1 9
D(4) dopamine receptor ligand AGN-PC-0073PO family 7 10
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
Survival motor neuron protein and Lysine-specific demethylase ... 1 16
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 7 0
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-(4-... 2 6
Histamine H1 receptor and C-C chemokine receptor type 3 ligand... 2 2
Histamine H3 receptor ligand AGN-PC-0765YW family 1 4
Sodium-dependent noradrenaline transporter and Sodium-dependen... 14 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 0
Histamine H3 receptor ligand AGN-PC-01WABH family 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-073OMG... 3 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Sigma non-opioid intracellular receptor 1 ligand 1-(3-fluoropr... 2 0
Sigma non-opioid intracellular receptor 1 ligand SureCN7450653... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 1
Amine oxidase [flavin-containing] B and Membrane primary amine... 1 1
Neuronal acetylcholine receptor subunit alpha-10 ligand SureCN... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00325641 CHEMBL540289 Bioactive SureCN467170
CFAMM00325630 CHEMBL542873 Bioactive 1-[(2R)-1-(4-chlorophenoxy)propan-2-yl]-4-methylpiperidine;hydrochloride
CFAMM00325647 CHEMBL543821 Bioactive AGN-PC-07BZ55
CFAMM00325639 CHEMBL545691 Bioactive 1-[(2R)-4-(4-chlorophenoxy)butan-2-yl]-4-methylpiperidine;hydrochloride
CFAMM00325629 CHEMBL542392 Bioactive 1-[(2R)-2-(4-chlorophenoxy)propyl]-4-methylpiperidine;hydrochloride
CFAMM00325646 CHEMBL544524 Bioactive 1-[(2S)-4-(4-chlorophenoxy)butan-2-yl]-4-methylpiperidine;hydrochloride
CFAMM00325644 CHEMBL555790 Bioactive 1-[(2S)-1-(4-chlorophenoxy)propan-2-yl]-4-methylpiperidine;hydrochloride
CFAMM00325635 CHEMBL1202074 Bioactive 1-[3-[3-(4-chlorophenoxy)propoxy]propyl]-4-methylpiperidine;oxalic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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