CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16138
Family Name Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benzyl-5-oxopyrrolidine-2-carbonyl)amino]-3-[4-(pyridine-2-carbonylamino)phenyl]propanoic acid family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00437147 Functional Category Bioactive
Superfamily Prelamin-A/C and Integrin beta-1 Binder Superfamily
Class Class 1941

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
HIV-1 protease Inhibitor Atazanavir Family 16 58
Folate receptor gamma Ligand Folic Acid Family 4 100
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Prothrombin Inhibitor Ximelegatran Family 8 157
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Substance-P receptor Ligand GSK424887 Family 8 184
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
CP-18770 family 6 27
JAK Inhibitor Momelotinib Family 33 83
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
PF-4136309 family 16 27
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Integrin beta-1 and Integrin alpha-4 Inhibitor MK-0668 Family 46 20
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-03RR5Q f... 3 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(3,5... 28 18
Pol polyprotein inhibitor AC1LAD48 family 19 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Cholecystokinin receptor type A ligand A-65186 family 2 6
Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Pol polyprotein inhibitor N-[3-[[(4R,5R,6R)-4-benzyl-5-hydroxy... 1 0
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Pol polyprotein and Protease inhibitor Palinavir family 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
C-C chemokine receptor type 5 ligand AC1LA25C family 3 6
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 3 14
C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Integrin beta-1 and Integrin alpha-4 inhibitor (Z)-2-[[(4S)-3-... 2 1
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Prothrombin and Trypsin-1 inhibitor 1-[2-(4-benzylpiperidin-1-... 2 2
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[2-(1H-ind... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[[(E)-3-(3,4-dichlo... 6 1
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Gastrin/cholecystokinin type B receptor ligand (2R)-2-[[5-(8-a... 2 3
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-4-methy... 2 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Renin inhibitor tert-butyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl-3,4... 2 2
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(3,5... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 2 3
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5367895 f... 3 0
Angiotensin-converting enzyme and Endothelin-converting enzyme... 1 0
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-[3-(dimethylamino)... 106 49
Melanin-concentrating hormone receptor 1 ligand SureCN4917950 ... 3 5
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-3-[4-[4-[[... 2 0
Calcium/calmodulin-dependent protein kinase type II subunit de... 1 0
Pol polyprotein inhibitor AC1LA6OV family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00437147 CHEMBL350953 Bioactive (2S)-2-[(1-benzyl-5-oxopyrrolidine-2-carbonyl)amino]-3-[4-(pyridine-2-carbonylamino)phenyl]propanoic acid
CFAMM00437145 CHEMBL443813 Bioactive (2S)-2-[[(2S)-1-benzyl-5-oxopyrrolidine-2-carbonyl]amino]-3-[4-(1,3-dioxopyrrolo[3,4-c]pyridin-2-yl)phenyl]propanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27526 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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