CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1616
Family Name 5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine receptor 3B ligand 4-(4-ethylpiperazin-1-yl)pyrrolo[1,2-a]quinoxaline family
No. of Seeds 7 No. of Other Members 4
Family Centroid CFAMM00325691 Functional Category Bioactive
Superfamily D(4) dopamine receptor Ligand A-425444 Superfamily
Class Class 1333

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Alpha-2A adrenergic receptor Ligand Brimonidine Family 3 6
Histamine H1 receptor Ligand Emedastine Family 5 115
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Transient receptor potential cation channel subfamily V member... 6 66
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
GDC-0349 family 44 77
C-Jun N-terminal kinase Inhibitor CC-930 Family 2 9
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Tryptase Inhibitor Babim Family 12 90
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Farnesyl pyrophosphate synthase Inhibitor Minodronate Family 1 0
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Thromboxane-A synthase Inhibitor CGS-13080 Family 3 19
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
Cathepsin K Inhibitor 2-cyclohexylamino-pyridine-2-carbonitril... 1 2
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Transient receptor potential cation channel subfamily V member... 2 26
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Aromatase Inhibitor NSC-356781 Family 3 10
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Farnesyl pyrophosphate synthase Inhibitor [2-(benzoimidazol-1-... 2 16
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
D(2) dopamine receptor Ligand PD-135146 Family 5 11
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
5-hydroxytryptamine receptor 1A Ligand CGS-12066B Family 1 0
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN5... 6 24
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 7
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
Platelet-activating factor receptor ligand SureCN9383514 family 4 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Vascular endothelial growth factor receptor 2 and Mitogen-acti... 2 2
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Sorbitol dehydrogenase inhibitor SureCN6335187 family 2 6
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 2 2
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 5 2
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 1
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... 7 6
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 8-... 6 2
Adenosine deaminase inhibitor AGN-PC-00FYYU family 4 5
Ribosomal protein S6 kinase alpha-5 inhibitor AGN-PC-075HAD fa... 2 0
Histamine H4 receptor and Histamine H3 receptor ligand (E)-[(3... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 0
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 0
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
C-C chemokine receptor type 3 ligand 5-fluoro-1-[1-[3-(4-fluor... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Tyrosine-protein kinase JAK1 and Aurora kinase A inhibitor CHE... 2 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Motilin receptor ligand SureCN2004322 family 2 1
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Cathepsin K inhibitor SureCN4141224 family 3 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Adenosine receptor A1 and Adenosine receptor A2b ligand SureCN... 2 3
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 10 1
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 3 6
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Serine/threonine-protein kinase B-raf inhibitor imidazole-base... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-b]pyridazine d... 2 1
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Microtubule-associated protein tau and Thyrotropin receptor li... 1 2
Survival motor neuron protein and 15-hydroxyprostaglandin dehy... 1 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Pyruvate kinase PKM inhibitor 2-(benzimidazol-1-ylmethyl)-6-me... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 3A and Histamine H4 receptor liga... 1 0
Tyrosyl-DNA phosphodiesterase 1 and Inositol monophosphatase 1... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00325694 CHEMBL523716 Bioactive 2-[4-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)piperazin-1-yl]-N'-hydroxyethanimidamide
CFAMM00325692 CHEMBL136449 Bioactive 2-[4-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)piperazin-1-yl]ethanol
CFAMM00325691 CHEMBL122835 Bioactive 4-(4-ethylpiperazin-1-yl)pyrrolo[1,2-a]quinoxaline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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