CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16161
Family Name Adenosine kinase inhibitor AGN-PC-0757MS family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00437220 Functional Category Bioactive
Superfamily Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-aminobutyric acid receptor subunit gamma-2 Binder Superfamily 5
Class Class 1070

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
MK-3328 family 2 32
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
MK-6096 family 3 69
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Serine/threonine-protein kinase Chk1 Inhibitor N-(5,6-diphenyl... 9 100
Fatty-acid amide hydrolase 1 Inhibitor 1-(oxazolo[4,5-b]pyridi... 19 34
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Sodium-dependent serotonin transporter Inhibitor 4-furan-2-yl-... 2 10
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Potassium voltage-gated channel subfamily H member 2 and Neuro... 3 4
Receptor-type tyrosine-protein kinase FLT3 and Hepatocyte grow... 7 56
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 5 8
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 2 3
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Histamine H4 receptor and Histamine H3 receptor ligand 7-(fura... 2 2
Vascular endothelial growth factor receptor 1 and Receptor-typ... 2 11
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 3
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 4 1
Vascular endothelial growth factor receptor 1 ligand CHEMBL197... 1 2
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
MAP kinase-activated protein kinase 2 inhibitor 4-[5-[4-(4-pip... 1 11
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Activated CDC42 kinase 1 inhibitor 6-[4-(2-morpholin-4-ylethox... 7 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Scavenger receptor class B member 1 ligand 2-[9-[3-(4,6-dimeth... 1 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 4
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-03J2ZU f... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 0
Histamine H3 receptor ligand 9-[2-(4-piperidin-1-ylpiperidin-1... 1 3
MAP kinase-activated protein kinase 2 inhibitor 3-[5-(4-chloro... 6 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00437220 CHEMBL354370 Bioactive AGN-PC-0757MS
CFAMM00437219 CHEMBL449402 Bioactive 5-(1-benzofuran-2-yl)-6-[2-(6-morpholin-4-ylpyridin-3-yl)ethynyl]pyrimidin-4-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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