CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1617
Family Name D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-chloro-2-methoxyphenyl)-4-[[(1S,2S)-2-phenylcyclopropyl]methyl]piperazine;hydrobromide family
No. of Seeds 3 No. of Other Members 5
Family Centroid CFAMM00288278 Functional Category Bioactive
Superfamily P2X purinoceptor 7 and D(2) dopamine receptor Binder Superfamily
Class Class 217

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
D(4) dopamine receptor ligand AGN-PC-004XJQ family 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 10
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Alpha-2A adrenergic receptor and 5-hydroxytryptamine receptor ... 7 10
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 0
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 2 3
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
Translocator protein inhibitor AGN-PC-00CH84 family 3 0
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 3 1
Progesterone receptor ligand CHEMBL253735 family 2 0
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 5-chloro-3... 2 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
D(2) dopamine receptor and D(3) dopamine receptor ligand 1-(3-... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00325701 CHEMBL1202205 Bioactive 1-(5-chloro-2-methoxyphenyl)-4-[[(1S,2S)-2-phenylcyclopropyl]methyl]piperazine;hydrobromide
CFAMM00325699 CHEMBL1202206 Bioactive 1-(2,4-dichlorophenyl)-4-[[(1S,2S)-2-(4-methoxyphenyl)cyclopropyl]methyl]piperazine;hydrobromide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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