CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16317
Family Name Coagulation factor X inhibitor AGN-PC-078Y0T family
No. of Seeds 11 No. of Other Members 0
Family Centroid CFAMM00437747 Functional Category Bioactive
Superfamily Coagulation factor X and C-X-C chemokine receptor type 3 Binder Superfamily
Class Class 2337

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Prothrombin Inhibitor Ximelegatran Family 8 157
Smoothened homolog Inhibitor Vismodegib Family 1 19
Transient receptor potential cation channel subfamily V member... 16 295
Neuromedin-K receptor Ligand SB222200 Family 17 235
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
ABC294640 family 5 75
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Stress kinase p38 Inhibitor P38 Map Kinase Inhibitor Family 1 3
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Peroxisome proliferator-activated receptor gamma Ligand 2-chlo... 5 19
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
Rho-associated protein kinase 2 inhibitor N-(7-chloro-1-oxo-2H... 1 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H... 4 38
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Metabotropic glutamate receptor 2 ligand AGN-PC-00A1HD family 2 0
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Reverse transcriptase/RNaseH inhibitor AGN-PC-0755HU family 1 0
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Prothrombin inhibitor AGN-PC-09QLAK family 10 2
Coagulation factor X and Kallikrein-1 inhibitor SureCN890858 f... 5 6
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
Nicotinamide phosphoribosyltransferase inhibitor 4-[[(7-chloro... 1 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[3-(4-chlorop... 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Tyrosine-protein kinase receptor TYRO3 and Mitogen-activated p... 3 7
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Glutamate receptor 1 and Glutamate receptor 2 ligand cp-465022... 1 6
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[4-oxo-3-(4-p... 2 1
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 3 0
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3
Sonic hedgehog protein and Cytochrome P450 2C9 inhibitor AGN-P... 1 0
C-C chemokine receptor type 3 ligand 4-[[2-(4-chlorophenyl)eth... 2 1
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [2-(a... 1 2
Potassium voltage-gated channel subfamily KQT member 3 and Pot... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00437748 CHEMBL513981 Bioactive SureCN12132362
CFAMM00437741 CHEMBL515254 Bioactive AGN-PC-078Y0Y
CFAMM00437747 CHEMBL472968 Bioactive AGN-PC-078Y0T
CFAMM00437746 CHEMBL471774 Bioactive AGN-PC-078Y4B
CFAMM00437745 CHEMBL472966 Bioactive 5-chloro-N-(5-chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-3-[ethyl(methyl)amino]benzamide
CFAMM00437744 CHEMBL514312 Bioactive SureCN10181927
CFAMM00437750 CHEMBL366358 Bioactive 5-chloro-N-(5-chloropyridin-2-yl)-2-[[4-[[4,5-dihydro-1,3-oxazol-2-yl(methyl)amino]methyl]benzoyl]amino]benzamide
CFAMM00437743 CHEMBL473161 Bioactive AGN-PC-078Y0U
CFAMM00437749 CHEMBL514616 Bioactive SureCN12132914
CFAMM00437742 CHEMBL470720 Bioactive AGN-PC-078Y3I

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

42899 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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