CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16347
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-dihydro-1-benzofuran-5-yl)-2-(6-pyridin-2-ylpyridin-3-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00437831 Functional Category Bioactive
Superfamily cGMP-specific 3',5'-cyclic phosphodiesterase and Cathepsin S Binder Superfamily
Class Class 976

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Multidrug resistance protein 3 Inhibitor LY335979 Family 1 3
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
PF-02545920 family 16 140
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Squalene synthase Inhibitor ER-119884 Family 2 3
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
5-hydroxytryptamine receptor 1A ligand AGN-PC-00JMV0 family 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
D(2) dopamine receptor ligand 129722-25-4 family 2 2
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Hepatocyte growth factor receptor ligand AGN-PC-08XYVH family 1 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 9 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN6575591... 2 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Platelet-derived growth factor receptor beta and Receptor-type... 1 2
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Platelet-derived growth factor receptor beta and Macrophage co... 8 0
Beta-secretase 1 inhibitor (5S)-3'-(3,4-difluorophenyl)-7'-(2-... 4 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
Renin inhibitor SureCN6043852 family 2 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 18 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 18 0
B2 bradykinin receptor ligand SureCN13145573 family 7 6
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00437831 CHEMBL369259 Bioactive 3-(2,3-dihydro-1-benzofuran-5-yl)-2-(6-pyridin-2-ylpyridin-3-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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