Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Histamine H1 receptor Ligand Astemizole Family 7 240 Fibroblast growth factor receptor 3 Ligand BMS-582664 Family 2 23 Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91 Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30 SB1518 family 7 103 Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236 RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148 Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194 DNA Binder Bisbenzimide (hoechst 33258) Family 4 159 Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68 Tyrosine kinase Inhibitor PKI166 Family 17 198 Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83 Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64 Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35 D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100 Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57 Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23 Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8 Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3 Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22 Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15 Reverse transcriptase Inhibitor UK-129485 Family 23 221 cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83 Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4 Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18 Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7 Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4 Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1 Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16 cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10 cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3 Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11 Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5 Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12 DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3 Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0 Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2 D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4 Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4 Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11 Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0 cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4 Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2 Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7 Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7 Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0 Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27 Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1 Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2 Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1 Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2 Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0 Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0 Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11 cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0 Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2 Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0 Vascular endothelial growth factor receptor 1 and Fibroblast g... 3 7 Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2 Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14 Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4 Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5 Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3 Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0 Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 4 4 Collagenase 3 inhibitor 5-[4-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0 Sterol O-acyltransferase 1 inhibitor 1-[4-[2-(4,5-diphenyl-1H-... 1 0 Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2 cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0 D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1 Glucagon receptor ligand SureCN2647807 family 3 7 Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1 Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3 Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2 Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1 Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1 Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3 Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 4 Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1 Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1 D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3 Oxytocin receptor ligand AGN-PC-07C71T family 3 2 Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0 Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor AGN-PC... 2 0 D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0 Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0 cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1 Multidrug resistance-associated protein 1 inhibitor SureCN6823... 1 0 Neuropeptide Y receptor type 5 ligand 7-methoxy-2-methyl-6-phe... 1 1
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00325934 CHEMBL1203053 Bioactive
7-[3-[1-[1-(cyclohexylmethyl)piperidin-4-yl]tetrazol-5-yl]propoxy]-1,3-dihydroimidazo[4,5-b]quinolin-2-one;hydrochloride CFAMM00325933 CHEMBL1203034 Bioactive
7-[3-[1-[1-[(4-fluorophenyl)methyl]piperidin-4-yl]tetrazol-5-yl]propoxy]-1,3-dihydroimidazo[4,5-b]quinolin-2-one;hydrochloride CFAMM00325932 CHEMBL1203031 Bioactive
7-[3-[1-(1-benzylpiperidin-4-yl)tetrazol-5-yl]propoxy]-1,3-dihydroimidazo[4,5-b]quinolin-2-one;hydrochloride CFAMM00325925 CHEMBL88835 Bioactive
7-[3-(2H-tetrazol-5-yl)propoxy]-1,3-dihydroimidazo[4,5-b]quinolin-2-one CFAMM00325931 CHEMBL1203039 Bioactive
7-[3-[1-[1-(2-ethylbutyl)piperidin-4-yl]tetrazol-5-yl]propoxy]-1,3-dihydroimidazo[4,5-b]quinolin-2-one;hydrochloride CFAMM00325935 CHEMBL90120 Bioactive
7-[4-(2H-tetrazol-5-yl)butoxy]-1,3-dihydroimidazo[4,5-b]quinolin-2-one
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00325927 CHEMBL377346 Bioactive
(2E)-2-(5-phenylmethoxy-1,2-dihydroindazol-3-ylidene)-5-(4-piperidin-1-ylpiperidin-1-yl)benzimidazole CFAMM00325926 CHEMBL211662 Bioactive
(2E)-2-(5-phenoxy-1,2-dihydroindazol-3-ylidene)-5-(4-piperidin-1-ylpiperidin-1-yl)benzimidazole CFAMM00325928 CHEMBL209305 Bioactive
(2E)-2-(5-methoxy-1,2-dihydroindazol-3-ylidene)-5-(4-piperidin-1-ylpiperidin-1-yl)benzimidazole CFAMM00325930 CHEMBL209266 Bioactive
(2E)-2-[5-(4-methoxyphenoxy)-1,2-dihydroindazol-3-ylidene]-5-(4-piperidin-1-ylpiperidin-1-yl)benzimidazole CFAMM00325929 CHEMBL211508 Bioactive
(2E)-2-[5-(2-methoxyphenoxy)-1,2-dihydroindazol-3-ylidene]-5-(4-piperidin-1-ylpiperidin-1-yl)benzimidazole
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Chen Yuzong Deputy
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