CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16354
Family Name Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ligand (1S,15R,18S,19R,20S)-18-hydroxy-N-[8-[[(1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carbonyl]amino]octyl]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxamide;dihydrochloride family
No. of Seeds 9 No. of Other Members 3
Family Centroid CFAMM00437846 Functional Category Bioactive
Superfamily Alpha-2 adrenergic receptor Ligand Yohimbine Superfamily
Class Class 78

Cousin Family NamesSeedsMembers
Alpha-2 adrenergic receptor Ligand Yohimbine Family 7 52
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
HIV-1 protease Inhibitor Atazanavir Family 16 58
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Endothelin B receptor Ligand IRL-2500 Family 34 87
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 48


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00437851 CHEMBL369938 Bioactive benzyl N-[3-[[(1S,15R,18S,19R)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carbonyl]amino]propyl]carbamate
CFAMM00437844 CHEMBL554019 Bioactive (1S,15R,18S,19R,20S)-18-hydroxy-N-[10-[[(1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carbonyl]amino]decyl]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxamide;dihydrochloride
CFAMM00437850 CHEMBL555190 Bioactive (1S,15R,18S,19R,20S)-18-hydroxy-N-[5-[[(1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carbonyl]amino]pentyl]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxamide;dihydrochloride
CFAMM00437849 CHEMBL551711 Bioactive (1S,15R,18S,19R,20S)-18-hydroxy-N-[12-[[(1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carbonyl]amino]dodecyl]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxamide;dihydrochloride
CFAMM00437842 CHEMBL371516 Bioactive (1S,15R,18S,19R)-18-hydroxy-N-[3-[[(1R,15S,18R,19S,20R)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carbonyl]amino]propyl]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxamide
CFAMM00437848 CHEMBL542527 Bioactive (1S,15R,18S,19R,20S)-18-hydroxy-N-[6-[[(1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carbonyl]amino]hexyl]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxamide;dihydrochloride
CFAMM00437853 CHEMBL539606 Bioactive (1S,15R,18S,19R,20S)-18-hydroxy-N-[9-[[(1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carbonyl]amino]nonyl]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxamide;dihydrochloride
CFAMM00437846 CHEMBL538808 Bioactive (1S,15R,18S,19R,20S)-18-hydroxy-N-[8-[[(1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carbonyl]amino]octyl]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxamide;dihydrochloride
CFAMM00437852 CHEMBL543232 Bioactive (1S,15R,18S,19R,20S)-18-hydroxy-N-[7-[[(1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carbonyl]amino]heptyl]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxamide;dihydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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