CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16378
Family Name Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy-3,5-dimethylphenyl)-3-[(2S)-1-(2-phenylethylamino)propan-2-yl]-1H-indol-5-yl]-2-methyl-N,N-bis(2-methylpropyl)propanamide family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00437899 Functional Category Bioactive
Superfamily Melatonin receptor type 1A and Melatonin receptor type 1B Binder Superfamily 4
Class Class 3075

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Indeglitazar family 3 39
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... 3 0
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 2 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
C-X-C chemokine receptor type 2 ligand 4-[5-cyano-2-(4-fluorop... 1 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Bile acid receptor ligand SureCN1243717 family 1 4
Platelet-derived growth factor receptor beta and Vascular endo... 1 3
Oxysterols receptor LXR-beta ligand indole derivative, 39 family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00437899 CHEMBL371722 Bioactive 2-[2-(4-methoxy-3,5-dimethylphenyl)-3-[(2S)-1-(2-phenylethylamino)propan-2-yl]-1H-indol-5-yl]-2-methyl-N,N-bis(2-methylpropyl)propanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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