CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Thymidylate synthase inhibitor AC1LABAB family
No. of Seeds 14 No. of Other Members 3
Family Centroid CFAMM00308287 Functional Category Bioactive
Superfamily Thymidylate synthase Binder Superfamily
Class Class 1253

Cousin Family NamesSeedsMembers
Thymidylate synthase inhibitor (2S)-2-[[4-[(2-methyl-4-oxo-1,6... 15 107
Thymidylate synthase inhibitor (2R)-2-[[(4S)-4-carboxy-4-[[4-[... 55 43
Thymidylate synthase inhibitor AC1LAB82 family 17 0
Thymidylate synthase inhibitor AC1LAB7Z family 8 3
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-di... 3 1
Thymidylate synthase inhibitor (2S)-2-[[(4S)-4-carboxy-4-[[(4S... 7 11
Folylpolyglutamate synthase, mitochondrial and Dihydrofolate r... 3 0
Thymidylate synthase inhibitor SureCN6446340 family 2 1
Cationic trypsin and Prothrombin inhibitor 2-ketobenzothiazole... 1 3


External ID

Functional Category

Molecule Name

CFAMM00308293 CHEMBL341323 Bioactive AC1LAB9N
CFAMM00308286 CHEMBL338598 Bioactive (2S)-2-[[4-[(2,7-dimethyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]-2-fluorobenzoyl]amino]-3-(2H-tetrazol-5-ylsulfanyl)propanoic acid
CFAMM00308294 CHEMBL340814 Bioactive AC1LAB9Q
CFAMM00308292 CHEMBL55437 Bioactive (2S)-2-[[4-[(2-methyl-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]-5-(1H-1,2,4-triazol-5-ylsulfonyl)pentanoic acid
CFAMM00308300 CHEMBL126914 Bioactive AC1LAB9E
CFAMM00308285 CHEMBL337914 Bioactive AC1LAB9W
CFAMM00308291 CHEMBL103105 Bioactive (2S)-2-[[4-[[(6S)-2-methyl-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl]-prop-2-ynylamino]benzoyl]amino]-5-(1H-1,2,4-triazol-5-ylsulfonyl)pentanoic acid
CFAMM00308290 CHEMBL338644 Bioactive AC1LABA8
CFAMM00308298 CHEMBL127583 Bioactive AC1LAB9Z
CFAMM00308297 CHEMBL338429 Bioactive AC1LABA5
CFAMM00308288 CHEMBL420155 Bioactive AC1LAB9T
CFAMM00308296 CHEMBL126555 Bioactive (2S)-2-[[4-[(2,7-dimethyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]-2-fluorobenzoyl]amino]-3-(2H-tetrazol-5-ylsulfinyl)propanoic acid
CFAMM00308287 CHEMBL126325 Bioactive AC1LABAB
CFAMM00308295 CHEMBL105346 Bioactive AC1LABA2

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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