CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16420
Family Name Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ligand N-[[(2R,3R)-3-(4-chlorophenyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-2-(2,6-dimethoxyphenoxy)ethanamine family
No. of Seeds 1 No. of Other Members 2
Family Centroid CFAMM00438087 Functional Category Bioactive
Superfamily Substance-K receptor and Substance-P receptor Binder Superfamily 5
Class Class 4275

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Serotonin re-uptake Inhibitor Paroxetine Family 6 19
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
5-hydroxytryptamine receptor 1A Ligand MN-305 Family 12 26
Acolbifene family 10 115
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
D(4) dopamine receptor ligand AGN-PC-0073PO family 7 10
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 3
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 7 4
Sodium-dependent serotonin transporter inhibitor 3-(3,4-dichlo... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 5 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 6 21
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 0
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00438087 CHEMBL37477 Bioactive N-[[(2R,3R)-3-(4-chlorophenyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-2-(2,6-dimethoxyphenoxy)ethanamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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