CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16430
Family Name RAC-alpha serine/threonine-protein kinase and RAC-gamma serine/threonine-protein kinase inhibitor (2S)-1-[6-(furan-3-yl)-5-(3-methyl-2H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-3-yl]oxy-3-(1H-indol-3-yl)propan-2-amine family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00258426 Functional Category Bioactive
Superfamily RAC-alpha serine/threonine-protein kinase and Aurora kinase B Binder Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
PF-02545920 family 16 140
Adenosine receptor A1 and Adenosine receptor A2a Ligand CGS-15... 24 47
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 4
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Adenosine receptor A2a ligand 7-(3,4-dimethoxyphenyl)-2-(furan... 6 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 4
Tyrosine-protein kinase ITK/TSK and Aurora kinase B inhibitor ... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN4806204 f... 13 7
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 2 0
Coagulation factor X inhibitor AGN-PC-046RMQ family 1 0
Rho-associated protein kinase 2 inhibitor SureCN13457632 family 1 1
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Protein kinase C theta type and Protein kinase C delta type in... 5 4
Collagenase 3 inhibitor SureCN1316041 family 4 3
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00438112 CHEMBL605838 Bioactive (2S)-1-[6-(furan-3-yl)-5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxy-3-(1H-pyrrolo[3,2-b]pyridin-3-yl)propan-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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