CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16432
Family Name Transient receptor potential cation channel subfamily V member 1 ligand 3-amino-5-[2-(2-methoxyethylamino)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1H-quinoxalin-2-one family
No. of Seeds 18 No. of Other Members 1
Family Centroid CFAMM00438125 Functional Category Bioactive
Superfamily Neuropeptide Y receptor type 1 and Glutamate receptor ionotropic, NMDA 1 Binder Superfamily
Class Class 1268

Cousin Family NamesSeedsMembers
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
SB1518 family 7 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Transient receptor potential cation channel subfamily V member... 2 4
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Transient receptor potential cation channel subfamily V member... 2 0
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
TGF-beta receptor type-1 ligand SureCN373216 family 3 14


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00438133 CHEMBL511393 Bioactive 3-amino-5-[6-[2-(2-morpholin-4-ylethylamino)-6-(trifluoromethyl)pyridin-3-yl]pyrimidin-4-yl]oxy-1H-quinoxalin-2-one
CFAMM00438126 CHEMBL513151 Bioactive 3-amino-5-[6-[2-amino-4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1H-quinoxalin-2-one
CFAMM00438119 CHEMBL494796 Bioactive SureCN4816159
CFAMM00438132 CHEMBL448574 Bioactive SureCN5142887
CFAMM00438125 CHEMBL493806 Bioactive 3-amino-5-[2-(2-methoxyethylamino)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1H-quinoxalin-2-one
CFAMM00438118 CHEMBL511766 Bioactive 3-amino-5-[6-[2-amino-4-(trifluoromethyl)phenyl]-2-(2-methoxyethylamino)pyrimidin-4-yl]oxy-1H-quinoxalin-2-one
CFAMM00438131 CHEMBL469234 Bioactive 3-amino-5-[2-amino-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1H-quinoxalin-2-one
CFAMM00438124 CHEMBL375681 Bioactive 4-Oxopyrimidine, 32
CFAMM00438117 CHEMBL468751 Bioactive 3-amino-5-[6-[2-(2-methoxyethylamino)-6-(trifluoromethyl)pyridin-3-yl]pyrimidin-4-yl]oxy-1H-quinoxalin-2-one
CFAMM00438130 CHEMBL469235 Bioactive SureCN4810708
CFAMM00438123 CHEMBL494634 Bioactive 3-amino-5-[2-(3-hydroxybutylamino)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1H-quinoxalin-2-one
CFAMM00438129 CHEMBL468200 Bioactive SureCN4809237
CFAMM00438116 CHEMBL468752 Bioactive 3-amino-5-[6-[2-[[(2S)-oxolan-2-yl]amino]-6-(trifluoromethyl)pyridin-3-yl]pyrimidin-4-yl]oxy-1H-quinoxalin-2-one
CFAMM00438122 CHEMBL494635 Bioactive SureCN14268177
CFAMM00438115 CHEMBL468653 Bioactive 3-amino-5-[6-[2-amino-6-(trifluoromethyl)pyridin-3-yl]pyrimidin-4-yl]oxy-1H-quinoxalin-2-one
CFAMM00438128 CHEMBL510372 Bioactive SureCN4818570
CFAMM00438121 CHEMBL468959 Bioactive SureCN4817807
CFAMM00438127 CHEMBL467601 Bioactive 1-[2-[6-[(3-amino-2-oxo-1H-quinoxalin-5-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]-3-tert-butylurea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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