CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16434
Family Name Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)methyl]-2-[1-(2-imidazol-1-ylpyrimidin-4-yl)piperidin-2-yl]acetamide family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00438137 Functional Category Bioactive
Superfamily Prostaglandin D2 receptor and Lysosomal Pro-X carboxypeptidase Binder Superfamily
Class Class 2568

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Prothrombin Inhibitor Dabigatran Family 7 182
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
HCV NS4B protein Inhibitor Clemizole Family 2 43
RAC-gamma serine/threonine-protein kinase Inhibitor GDC-0068 F... 20 29
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
GDC-0349 family 44 77
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Histamine H3 receptor Ligand SCH79687 Family 11 29
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Cannabinoid receptor 1 Ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 18 41
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5856722 family 3 16
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... 5 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 9 31
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 5 3
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(3,4-di... 3 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Bile acid receptor and Potassium voltage-gated channel subfami... 2 1
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 14
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 1
Signal transducer and activator of transcription 6 inhibitor A... 3 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Lysosomal Pro-X carboxypeptidase inhibitor methyl N-[4-[[6-[[(... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Substance-P receptor ligand SureCN7659714 family 2 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 2 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN9931311 family 2 0
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 6 3
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-[2-(trif... 1 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
C-C chemokine receptor type 5 ligand N-[3-[4-[3-cyclohexyl-5-(... 5 4
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Substance-K receptor ligand SureCN9035669 family 10 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Coagulation factor X inhibitor SureCN1652469 family 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cathepsin S and Cathepsin K inhibitor 2-cyano-N-[(2R)-1-phenyl... 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (3... 1 1
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R96X family 7 1
Dihydrofolate reductase inhibitor 5-[(7-chloro-10-methylsulfan... 1 0
P2X purinoceptor 7 inhibitor N-[(3-chloro-2-methylphenyl)methy... 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00438137 CHEMBL376237 Bioactive N-[(4-chlorophenyl)methyl]-2-[1-(2-imidazol-1-ylpyrimidin-4-yl)piperidin-2-yl]acetamide
CFAMM00438136 CHEMBL598842 Bioactive SureCN2780589

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26197 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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