CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1645
Family Name Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ligand AGN-PC-046YIA family
No. of Seeds 2 No. of Other Members 7
Family Centroid CFAMM00174106 Functional Category Bioactive
Superfamily Disintegrin and metalloproteinase domain-containing protein 17 Binder Superfamily 2
Class Class 297

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Muscarinic acetylcholine receptor M2 and Acetylcholinesterase ... 4 24
Plasmepsin-2 inhibitor N-[(2S)-1-[[(2S)-6-amino-1-[4-[(6-metho... 5 12
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Histamine H3 receptor ligand SureCN2784306 family 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Somatostatin receptor type 2 ligand SureCN4325675 family 3 1
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Disintegrin and metalloproteinase domain-containing protein 17... 1 2
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Cholinesterase and Acetylcholinesterase inhibitor 5-hydroxy-7-... 5 19
Acetylcholinesterase and Cholinesterase inhibitor N-[10-[(6-ch... 6 0
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Cholinesterase and Acetylcholinesterase inhibitor tacrine deri... 10 0
Cholinesterase and Acetylcholinesterase inhibitor 6-[4-[2-fluo... 17 0
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-073E7... 2 4
Disintegrin and metalloproteinase domain-containing protein 17... 5 0
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Gonadotropin-releasing hormone receptor ligand 7-chloro-3-(3,5... 2 1
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN5... 4 1
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Prothrombin inhibitor AGN-PC-074I2Z family 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Bile acid receptor ligand SureCN1243717 family 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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