CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16450
Family Name Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00438215 Functional Category Bioactive
Superfamily Platelet-derived growth factor receptor beta and Vascular endothelial growth factor receptor 2 Binder Superfamily
Class Class 877

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Histamine H1 receptor Ligand Mizolastine Family 14 603
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
SB989 family 17 91
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H... 4 38
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Histamine H4 receptor ligand SureCN602132 family 1 8
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Lysosomal Pro-X carboxypeptidase inhibitor 2-amino-N-[(2S)-1-[... 11 16
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... 2 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 18
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
Cytochrome P450 3A4 and Insulin-like growth factor 1 receptor ... 24 57
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 6 6
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 1
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 10 1
Macrophage colony-stimulating factor 1 receptor and Receptor-t... 2 0
Substance-K receptor ligand SureCN9035669 family 10 5
Coagulation factor X inhibitor SureCN1652469 family 2 1
Gonadotropin-releasing hormone receptor and 5-hydroxytryptamin... 2 0
Melanin-concentrating hormone receptor 1 ligand SureCN3832854 ... 3 2
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00438215 CHEMBL377312 Bioactive CHIR-124

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27619 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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