CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16499
Family Name Cathepsin S and Cathepsin L1 inhibitor (2S)-2-(1,3-benzoxazol-2-ylamino)-3-cyclohexyl-N-[(2R)-1-(5-fluoro-2,3-dihydroindol-1-yl)-3-phenylmethoxypropan-2-yl]propanamide family
No. of Seeds 1 No. of Other Members 9
Family Centroid CFAMM00438398 Functional Category Bioactive
Superfamily Integrin alpha-4 and Cathepsin S Binder Superfamily
Class Class 678

Cousin Family NamesSeedsMembers
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Chymase Inhibitor Y-40613 Family 11 56
Peroxisome proliferator-activated receptor gamma Ligand SB-213... 2 54
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
Arachidonate 5-lipoxygenase Inhibitor 5-chloro-n-phenylbenzo[d... 3 15
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Arachidonate 5-lipoxygenase Inhibitor 5-methyl-n-phenylbenzo[d... 5 13
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 5 25
Somatostatin receptor type 5 and Potassium voltage-gated chann... 2 21
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(2-oxo-3... 2 11
5-hydroxytryptamine receptor 3A ligand 2-[(3S)-3-ethylmorpholi... 10 18
Neutrophil elastase inhibitor 1-N-[(2S)-1-[(2S)-2-[[(2S)-1-(1,... 7 1
Neutrophil elastase inhibitor methyl 2-[(2S)-3-methyl-2-[[(2S)... 2 0
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Pol polyprotein inhibitor (2S)-4-(1,3-benzoxazol-2-ylmethyl)-1... 1 0
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Cannabinoid receptor 2 ligand [4-(5-tert-butyl-1,3-benzoxazol-... 4 1
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
Melanin-concentrating hormone receptor 1 ligand N-[3-(2-aminoq... 4 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S,... 2 3
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1,3-benzoxazol... 3 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Prostaglandin E synthase inhibitor 1-[5-chloro-6-(4-fluorophen... 8 27
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,5S)-5-(... 20 10
Cathepsin S inhibitor (2S,4R)-4-(benzenesulfonyl)-N-[1-(1,3-be... 4 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 5 2
Coagulation factor X and Plasma kallikrein inhibitor (2R)-N-[2... 1 0
Neutrophil elastase inhibitor methyl 2-[(2S)-2-[[(2S)-1-[(2S)-... 3 0
Cathepsin S and Cathepsin L1 inhibitor SureCN5361439 family 2 4
Integrin alpha-4 inhibitor (5R)-5-[[(2R)-2-[[2-[4-(1,3-benzoxa... 2 0
5-hydroxytryptamine receptor 6 ligand SureCN3910449 family 3 15
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,4S)-1-[... 2 0
Somatostatin receptor type 5 ligand SureCN3572493 family 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00438398 CHEMBL380756 Bioactive (2S)-2-(1,3-benzoxazol-2-ylamino)-3-cyclohexyl-N-[(2R)-1-(5-fluoro-2,3-dihydroindol-1-yl)-3-phenylmethoxypropan-2-yl]propanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27061 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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