CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM165
Family Name Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-5-benzyl-3-hydroxy-6-[[(3S,4R)-3-hydroxy-3,4-dihydro-2H-chromen-4-yl]amino]-6-oxo-1-phenylhexan-2-yl]carbamate family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00308306 Functional Category Bioactive
Superfamily Calpain-1 catalytic subunit and Pol polyprotein Binder Superfamily
Class Class 609

Cousin Family NamesSeedsMembers
HIV-1 protease Inhibitor Lopinavir Family 4 25
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Pol polyprotein inhibitor 180968-31-4 family 8 13
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Pol polyprotein inhibitor MK-944a family 6 1
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Pol polyprotein inhibitor MDL 74538 family 11 1
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 0
NS3 inhibitor Proline-Based Macrocycle 24 family 6 6
Pol polyprotein inhibitor L-689,502 family 17 2
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-d... 10 15
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-4-[[(4S)... 4 0
Pol polyprotein inhibitor SDZ PRI 053 family 8 1
Pol polyprotein inhibitor AC1LA3AI family 5 9
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Pol polyprotein inhibitor AC1L9XVT family 4 0
Pol polyprotein inhibitor AC1LA3B0 family 1 2
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
Renin inhibitor methyl N-[[5-[[(2S,3S,5R)-2-amino-6-(butylamin... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00308304 CHEMBL111143 Bioactive AC1O5CE4
CFAMM00308306 CHEMBL103213 Bioactive tert-butyl N-[(2S,3S,5R)-5-benzyl-3-hydroxy-6-[[(3S,4R)-3-hydroxy-3,4-dihydro-2H-chromen-4-yl]amino]-6-oxo-1-phenylhexan-2-yl]carbamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26413 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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