CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16557
Family Name Tyrosine-protein kinase Lck and Mitogen-activated protein kinase 14 inhibitor AGN-PC-00SRAC family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00172756 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 14 and Tyrosine-protein kinase Lck Binder Superfamily 2
Class Class 831

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
DCC-2036 family 2 5
Smoothened homolog Inhibitor LDE225 Family 3 76
SB1518 family 7 103
MK-6096 family 3 69
JAK Inhibitor Momelotinib Family 33 83
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 6 13
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Angiopoietin-1 receptor ligand SureCN1939461 family 1 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 7
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 1
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Gonadotropin-releasing hormone receptor ligand 4-[2-[(2S)-azet... 1 0
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Transient receptor potential cation channel subfamily V member... 2 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
Neuropeptide Y receptor type 5 ligand SureCN2658856 family 6 0
Tyrosine-protein kinase receptor Tie-1 and Receptor-type tyros... 1 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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