CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16575
Family Name Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-methoxyphenyl)-5H-pyrazolo[3,4-c]quinolin-4-one family
No. of Seeds 2 No. of Other Members 10
Family Centroid CFAMM00292007 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 12 Inhibitor ARRY-797 Superfamily
Class Class 842

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Mitogen-activated protein kinase 12 Inhibitor ARRY-797 Family 13 41
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... 15 18
Coagulation factor X Inhibitor Apixaban Family 34 52
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
DCC-2036 family 2 5
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 5 0
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Histamine H3 receptor ligand SureCN2784306 family 5 3
Sodium channel protein type 9 subunit alpha ligand AGN-PC-09QK... 1 19
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
5-hydroxytryptamine receptor 3A ligand 1-[4-[[7-(diethylamino)... 2 4
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
5-hydroxytryptamine receptor 3A ligand 5-hydroxy-1-methyl-N-[(... 4 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
Coagulation factor X inhibitor SureCN6785555 family 7 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-(cy... 3 2
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 0
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 7-met... 2 1
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Poly [ADP-ribose] polymerase 1 inhibitor 1-(4-methoxyphenyl)-3... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Coagulation factor X inhibitor AGN-PC-046RMQ family 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 2 3
Coagulation factor X inhibitor AGN-PC-077MYE family 16 0
Coagulation factor X inhibitor SureCN5644036 family 30 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family 4 3
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Diacylglycerol O-acyltransferase 1 inhibitor AGN-PC-07ZCRO family 1 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 0
Vascular endothelial growth factor receptor 2 ligand (4Z)-4-[(... 3 0
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Dual specificity mitogen-activated protein kinase kinase 1 inh... 2 5
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Platelet-derived growth factor receptor beta and Vascular endo... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00438658 CHEMBL593828 Bioactive AGN-PC-07R6TJ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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