CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1660
Family Name 5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic receptor ligand 2-[4-[4-(1,3-dioxo-5,6,7,7a-tetrahydropyrrolo[1,2-c]imidazol-2-yl)butyl]piperazin-1-yl]benzonitrile;hydrochloride family
No. of Seeds 5 No. of Other Members 14
Family Centroid CFAMM00326111 Functional Category Bioactive
Superfamily Dipeptidyl peptidase 4 and Androgen receptor Binder Superfamily
Class Class 1613

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Alpha adrenergic receptor Ligand Droperidol Family 20 244
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 9 19
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Androgen receptor Ligand YM-175735 Family 30 129
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
D(2) dopamine receptor Ligand PD-168077 Family 6 5
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand methy... 2 11
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 5 5
B2 bradykinin receptor ligand AGN-PC-074WA4 family 2 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 6
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 3
Calcitonin gene-related peptide type 1 receptor and Dual speci... 8 4
5-hydroxytryptamine receptor 1A ligand AGN-PC-080K14 family 3 3
Androgen receptor ligand SureCN6096119 family 7 2
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-anilinopyrr... 2 13
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Histamine H3 receptor and Histamine receptor H3 ligand N-[4-[3... 5 1
Histamine H3 receptor and Histamine receptor H3 ligand 1-cyclo... 3 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
Histamine receptor H3 ligand N-[2-methyl-4-[(3S)-3-[(2S)-2-met... 10 7
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 3 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Aldose reductase inhibitor Spiro-cimqat family 6 8
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Aldose reductase inhibitor (4R)-6-fluoro-3-methylspiro[1H-quin... 4 16
Aldose reductase inhibitor SureCN10775957 family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00326107 CHEMBL61614 Bioactive 2-[4-[4-(1,3-dioxo-5,6,7,7a-tetrahydropyrrolo[1,2-c]imidazol-2-yl)butyl]piperazin-1-yl]benzonitrile
CFAMM00326111 CHEMBL1204235 Bioactive 2-[4-[4-(1,3-dioxo-5,6,7,7a-tetrahydropyrrolo[1,2-c]imidazol-2-yl)butyl]piperazin-1-yl]benzonitrile;hydrochloride
CFAMM00326110 CHEMBL1204237 Bioactive 2-[4-[4-(2-methylphenyl)piperazin-1-yl]butyl]-5,6,7,7a-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione;hydrochloride
CFAMM00326117 CHEMBL417381 Bioactive AP-685/41280812

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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