CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16601
Family Name Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4-methoxyphenyl)pyrazolo[3,4-c]quinolin-4-yl]-2-phenylacetamide family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00291992 Functional Category Bioactive
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily 13
Class Class 855

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
DCC-2036 family 2 5
Smoothened homolog Inhibitor LDE225 Family 3 76
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
PHA848125 family 13 138
Tyrosine kinase Inhibitor PKI166 Family 17 198
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 6
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Adenosine receptor A1 ligand SureCN5012033 family 2 9
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 4 3
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Translocator protein inhibitor AGN-PC-080ILF family 9 3
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Coagulation factor X inhibitor AGN-PC-00FGDC family 11 5
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 5 19
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Hepatocyte growth factor receptor ligand 5-[[6-(3-hydroxypheny... 2 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 9
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Coagulation factor X and Prothrombin inhibitor 1-(4-methoxyphe... 8 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Adenosine receptor A1 ligand ethyl 1-(2-chloro-2-phenylethyl)-... 5 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Hepatocyte growth factor receptor ligand AGN-PC-00AG7Q family 1 10
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Coagulation factor X inhibitor 2-(4-methoxyphenyl)-N-[5-(2-sul... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor 1-(4-methoxyphenyl)-3... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Vascular endothelial growth factor receptor 2 and Vascular end... 2 3
Coagulation factor X inhibitor SureCN5641901 family 5 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 1 0
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 1 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family 4 3
Adenosine receptor A1 ligand 4-amino-2-phenyl-3H-pyrazolo[3,4-... 1 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 8 7
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 3 0
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00438730 CHEMBL397033 Bioactive N-[2-(4-methoxyphenyl)pyrazolo[3,4-c]quinolin-4-yl]-2,2-diphenylacetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

42616 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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