CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16620
Family Name Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family
No. of Seeds 24 No. of Other Members 5
Family Centroid CFAMM00438827 Functional Category Bioactive
Superfamily Type-1 angiotensin II receptor and Coagulation factor X Binder Superfamily
Class Class 1256

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Eluxadoline family 4 85
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
Melanin-concentrating hormone receptor 1 Ligand ADS-103214 Family 3 4
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Thromboxane A2 receptor ligand SureCN9045130 family 4 32
Thromboxane A2 receptor ligand AC1NSKJR family 13 42
Tyrosine-protein kinase ABL1 inhibitor AGN-PC-04S3QV family 1 2
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Mitogen-activated protein kinase 14 inhibitor DEL-B, 14b family 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 10 54
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 7 0
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
DNA-(apurinic or apyrimidinic site) lyase and Nuclear receptor... 2 10
Thyroid hormone receptor beta ligand CHEMBL1325165 family 1 6
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
NS5B protein inhibitor AC1LAMEZ family 1 18
Serine/threonine-protein kinase Chk2 inhibitor SureCN3919556 f... 4 8
Cytochrome P450 26A1 inhibitor AGN-PC-09MAZ3 family 1 7
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
NS5B protein inhibitor (2E)-1-cyclohexyl-2-(2-fluoro-4-oxocycl... 2 10
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 0
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 1... 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 29
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl... 2 1
Mu-type opioid receptor and Nitric oxide synthase, brain ligan... 3 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Type-1 angiotensin II receptor ligand N-[2-(3-methoxyphenyl)et... 2 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Coagulation factor X inhibitor AGN-PC-07C10A family 3 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Melanocortin receptor 4 ligand AGN-PC-076AMT family 2 9
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Bifunctional epoxide hydrolase 2 inhibitor 8-(1H-benzimidazole... 1 0
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 4 4
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Histamine H1 receptor and Substance-P receptor ligand SureCN13... 24 48
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN2... 1 2
Gonadotropin-releasing hormone receptor ligand 2-tert-butyl-8-... 6 23
Gonadotropin-releasing hormone receptor ligand AGN-PC-074DFG f... 2 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
NS5B protein and Genome polyprotein inhibitor AC1LAG00 family 1 19
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
C-C chemokine receptor type 5 ligand SureCN13543570 family 2 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Gastrin/cholecystokinin type B receptor ligand AGN-PC-077L8M f... 24 10
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Metabotropic glutamate receptor 2 ligand 2-[[(1R,5S)-6-[(2,5-d... 2 3
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RCV family 2 1
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07C5JC family 1 3
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 4
Platelet-activating factor receptor ligand 2-[4-(2-methylimida... 1 0
NS5B protein inhibitor AGN-PC-00HCFC family 1 1
Tryptase alpha/beta-1 and Tryptase delta inhibitor AGN-PC-0763... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00438824 CHEMBL472157 Bioactive AGN-PC-03LKZM
CFAMM00438837 CHEMBL512906 Bioactive AGN-PC-03LKX9
CFAMM00438816 CHEMBL487629 Bioactive AGN-PC-078V5T
CFAMM00438830 CHEMBL472121 Bioactive 2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-1-(furan-2-ylmethyl)benzimidazole-5-carboxamide
CFAMM00438823 CHEMBL471374 Bioactive 2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-1-(oxan-4-ylmethyl)benzimidazole-5-carboxamide
CFAMM00438836 CHEMBL453846 Bioactive AGN-PC-078V6S
CFAMM00438829 CHEMBL512886 Bioactive 2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-1-[[(2R)-oxolan-2-yl]methyl]benzimidazole-5-carboxamide
CFAMM00438815 CHEMBL488310 Bioactive SureCN5882005
CFAMM00438822 CHEMBL472506 Bioactive AGN-PC-078VF7
CFAMM00438835 CHEMBL453844 Bioactive AGN-PC-078V9O
CFAMM00438814 CHEMBL510072 Bioactive AGN-PC-078V7T
CFAMM00438828 CHEMBL471992 Bioactive AGN-PC-078VG5
CFAMM00438834 CHEMBL519592 Bioactive 2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-1-[[(2S)-1-methylpyrrolidin-2-yl]methyl]benzimidazole-5-carboxamide
CFAMM00438827 CHEMBL471980 Bioactive AGN-PC-03LKW5
CFAMM00438820 CHEMBL471558 Bioactive SureCN5882338
CFAMM00438833 CHEMBL453842 Bioactive AGN-PC-03LKYE
CFAMM00438826 CHEMBL454864 Bioactive AGN-PC-03LKVE
CFAMM00438825 CHEMBL454607 Bioactive AGN-PC-078V8V
CFAMM00438838 CHEMBL510854 Bioactive 1-(cyclopropylmethyl)-2-[(4-ethoxyphenyl)methyl]-N,N-bis(2,2,2-trifluoroethyl)benzimidazole-5-carboxamide
CFAMM00438831 CHEMBL507572 Bioactive AGN-PC-078V8W

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27430 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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