CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16657
Family Name RAF proto-oncogene serine/threonine-protein kinase inhibitor arylaminobenzimidazole, 23 family
No. of Seeds 8 No. of Other Members 6
Family Centroid CFAMM00438979 Functional Category Bioactive
Superfamily RAF proto-oncogene serine/threonine-protein kinase and Glucagon receptor Binder Superfamily
Class Class 681

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Serine/threonine-protein kinase PLK1 Inhibitor GSK461364 Family 40 84
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
DCC-2036 family 2 5
Smoothened homolog Inhibitor LDE225 Family 3 76
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
MK-6096 family 3 69
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
B2 bradykinin receptor Ligand FR-173657 Family 44 180
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Tyrosine-protein kinase Lyn and Tyrosine-protein kinase Lck in... 1 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 3
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 and Fibroblast g... 10 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Neuropeptide Y receptor type 5 and Alpha-1A adrenergic recepto... 8 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 8 8
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Elongation factor 1-alpha 1 and Elongation factor 1-alpha 2 in... 2 0
Renin inhibitor [2-(2,6-dimethylphenoxy)-6-methoxy-1-phenylpyr... 1 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 1... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-methyl-6-... 2 0
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor N-(2... 1 4
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 2
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 0
Vascular endothelial growth factor receptor 2 ligand N-[4-chlo... 2 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 5 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(1H-benzimidazole... 1 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 8 13
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
5-hydroxytryptamine receptor 6 ligand 2-[(2Z)-2-[3-[(3-methoxy... 1 11
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Transient receptor potential cation channel subfamily V member... 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 5 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-03J2ZU f... 1 2
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RCV family 2 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Vascular endothelial growth factor receptor 2 and Vascular end... 2 1
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-0766EI f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00438974 CHEMBL511997 Bioactive arylaminobenzimidazole, 12
CFAMM00438967 CHEMBL511836 Bioactive arylaminobenzimidazole, 24
CFAMM00438973 CHEMBL514135 Bioactive arylaminobenzimidazole, 27
CFAMM00438966 CHEMBL513562 Bioactive arylaminobenzimidazole, 20
CFAMM00438979 CHEMBL470808 Bioactive arylaminobenzimidazole, 23
CFAMM00438978 CHEMBL413621 Bioactive 2-aminobenzimidazole, 7
CFAMM00438971 CHEMBL395334 Bioactive 2-aminobenzimidazole, 19
CFAMM00438976 CHEMBL470591 Bioactive arylaminobenzimidazole, 21

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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