CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16694
Family Name 5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrrolo[2,3-b]pyridin-3-yl)sulfonylquinoline family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00439096 Functional Category Bioactive
Superfamily D(2) dopamine receptor and Interleukin-1 receptor type 1 Binder Superfamily
Class Class 914

Cousin Family NamesSeedsMembers
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... 11 18
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 13 100
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
5-hydroxytryptamine receptor 6 ligand 3-(5-chlorothiophen-2-yl... 6 1
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07CBUP family 2 3
Platelet-activating factor receptor ligand 6-(4-fluorophenyl)-... 1 3
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
5-hydroxytryptamine receptor 6 ligand 3-(3-chlorophenyl)sulfon... 8 1
5-hydroxytryptamine receptor 6 ligand 3-(3-bromophenyl)sulfony... 3 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-076AT1 family 7 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-0CSEAG family 2 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00439096 CHEMBL400608 Bioactive 8-(1-pyrrolidin-3-ylpyrrolo[2,3-b]pyridin-3-yl)sulfonylquinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26822 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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