CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16734
Family Name Beta-secretase 1 inhibitor N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-[(E)-N-methoxy-C-methylcarbonimidoyl]-5-(N-methylsulfonylanilino)benzamide family
No. of Seeds 5 No. of Other Members 5
Family Centroid CFAMM00439185 Functional Category Bioactive
Superfamily Beta-secretase 1 and Beta-secretase 2 Binder Superfamily
Class Class 3128

Cousin Family NamesSeedsMembers
Histamine H3 receptor Ligand A-349821 Family 49 228
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Beta-3 adrenergic receptor Ligand BMS-196085 Family 18 72
Beta-secretase 1 Inhibitor GSK-188909 Family 16 11
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Beta-secretase 1 and Cathepsin D inhibitor 3ixk family 2 9
Beta-secretase 1 and Cathepsin D inhibitor 3ixj family 10 21
Beta-secretase 1 inhibitor SureCN3599637 family 1 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN5224847 ... 3 24
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Pol polyprotein inhibitor AC1LA9K7 family 7 23
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Beta-secretase 1 inhibitor CHEMBL400438 family 5 16
Beta-secretase 1 and Beta-secretase 2 inhibitor 3-(1,1-dioxoth... 6 2
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Pol polyprotein inhibitor AC1LA3AI family 5 9
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Cathepsin E and Cathepsin D inhibitor SureCN2529506 family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00439188 CHEMBL553458 Bioactive N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-[(Z)-N-hydroxy-C-methylcarbonimidoyl]-5-(N-methylsulfonylanilino)benzamide
CFAMM00439187 CHEMBL541739 Bioactive N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-[(Z)-C-methyl-N-propoxycarbonimidoyl]-5-(N-methylsulfonylanilino)benzamide
CFAMM00439185 CHEMBL539975 Bioactive N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-[(E)-N-methoxy-C-methylcarbonimidoyl]-5-(N-methylsulfonylanilino)benzamide
CFAMM00439189 CHEMBL550271 Bioactive N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-[methyl(methylsulfonyl)amino]-5-[(Z)-C-methyl-N-phenylmethoxycarbonimidoyl]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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