CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1678
Family Name Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CC4 family
No. of Seeds 20 No. of Other Members 7
Family Centroid CFAMM00326342 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 and Beta-lactamase Binder Superfamily 2
Class Class 1248

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GSK561679 Family 5 6
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Tyrosine-protein kinase HCK and Proto-oncogene tyrosine-protei... 5 9
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 12 8
Translocator protein inhibitor AGN-PC-080ILF family 9 3
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 4
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Corticotropin-releasing factor receptor 1 ligand N-butyl-9-(2-... 4 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Neuropeptide Y receptor type 1 ligand CP-671906 family 10 0
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Corticotropin-releasing factor receptor 1 ligand AGN-PC-005GB4... 6 3
Voltage-dependent calcium channel subunit alpha-2/delta-1 and ... 9 15
Corticotropin-releasing factor receptor 1 ligand CHEMBL1819076... 2 0
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 17
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Estrogen receptor and Estrogen receptor beta ligand 4-[3-[4-(2... 1 0
Metabotropic glutamate receptor 2 ligand 8-chloro-3-(cycloprop... 6 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074EV8... 1 0
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4,... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCL... 3 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCI... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Corticotropin-releasing factor receptor 1 ligand [6-[cycloprop... 1 2
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 3 35


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00326328 CHEMBL484420 Bioactive AGN-PC-068CC0
CFAMM00326319 CHEMBL515396 Bioactive AGN-PC-068CC8
CFAMM00326347 CHEMBL121896 Bioactive SureCN5872522
CFAMM00326327 CHEMBL484421 Bioactive AGN-PC-068CCA
CFAMM00326340 CHEMBL521457 Bioactive AGN-PC-068CCB
CFAMM00326333 CHEMBL506214 Bioactive N-[(2R)-butan-2-yl]-8-(2,4-dimethoxy-6-methylphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
CFAMM00326346 CHEMBL120823 Bioactive N-(cyclopropylmethyl)-3-(2,4-dimethoxyphenyl)-2,5-dimethyl-N-propylpyrazolo[1,5-a]pyrimidin-7-amine
CFAMM00326325 CHEMBL474699 Bioactive AGN-PC-068CC5
CFAMM00326339 CHEMBL519999 Bioactive AGN-PC-068CC1
CFAMM00326332 CHEMBL473075 Bioactive AGN-PC-068CC7
CFAMM00326345 CHEMBL519677 Bioactive N-[(2S)-butan-2-yl]-8-(2,4-dimethoxy-6-methylphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
CFAMM00326338 CHEMBL121286 Bioactive N-butyl-3-(2,4-dimethoxyphenyl)-N-ethyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine
CFAMM00326331 CHEMBL473076 Bioactive AGN-PC-068CC9
CFAMM00326344 CHEMBL515740 Bioactive N-cyclopropyl-8-(2,4-dimethoxy-6-methylphenyl)-2,7-dimethyl-N-propylpyrazolo[1,5-a][1,3,5]triazin-4-amine
CFAMM00326330 CHEMBL484781 Bioactive AGN-PC-068CBY
CFAMM00326343 CHEMBL474498 Bioactive AGN-PC-068CC2
CFAMM00326329 CHEMBL474901 Bioactive AGN-PC-068CC6
CFAMM00326342 CHEMBL474499 Bioactive AGN-PC-068CC4
CFAMM00326320 CHEMBL295563 Bioactive AGN-PC-073OLH
CFAMM00326335 CHEMBL484408 Bioactive AGN-PC-068CBW

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543