Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421 Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140 Corticotropin-releasing factor receptor 1 Ligand GSK561679 Family 5 6 Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30 Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236 Ibrutinib family 2 27 Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35 Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23 Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48 Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16 Reverse transcriptase Inhibitor UK-129485 Family 23 221 Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18 Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0 Adenosine receptor A3 ligand CHEMBL1834696 family 5 18 Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11 Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20 Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2 Tyrosine-protein kinase HCK and Proto-oncogene tyrosine-protei... 5 9 Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 12 8 Translocator protein inhibitor AGN-PC-080ILF family 9 3 Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25 Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 4 Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6 Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11 D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6 Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5 Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22 Corticotropin-releasing factor receptor 1 ligand N-butyl-9-(2-... 4 5 Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1 Neuropeptide Y receptor type 1 ligand CP-671906 family 10 0 Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5 Corticotropin-releasing factor receptor 1 ligand AGN-PC-005GB4... 6 3 Voltage-dependent calcium channel subunit alpha-2/delta-1 and ... 9 15 Corticotropin-releasing factor receptor 1 ligand CHEMBL1819076... 2 0 Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1 TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2 Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1 Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 17 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0 Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1 Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2 Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2 Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 0 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0 Estrogen receptor and Estrogen receptor beta ligand 4-[3-[4-(2... 1 0 Metabotropic glutamate receptor 2 ligand 8-chloro-3-(cycloprop... 6 2 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5 Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2 Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0 cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0 Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0 Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0 Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6 Corticotropin-releasing factor receptor 1 ligand AGN-PC-074EV8... 1 0 Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0 Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4,... 2 2 Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5 Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3 Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5 Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCL... 3 0 Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCI... 3 0 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0 Glucokinase inhibitor AGN-PC-03ZE5E family 1 0 Corticotropin-releasing factor receptor 1 ligand [6-[cycloprop... 1 2 Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 3 35
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00326339 CHEMBL519999 Bioactive
AGN-PC-068CC1 CFAMM00326325 CHEMBL474699 Bioactive
AGN-PC-068CC5 CFAMM00326345 CHEMBL519677 Bioactive
N-[(2S)-butan-2-yl]-8-(2,4-dimethoxy-6-methylphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine CFAMM00326332 CHEMBL473075 Bioactive
AGN-PC-068CC7 CFAMM00326338 CHEMBL121286 Bioactive
N-butyl-3-(2,4-dimethoxyphenyl)-N-ethyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine CFAMM00326331 CHEMBL473076 Bioactive
AGN-PC-068CC9 CFAMM00326344 CHEMBL515740 Bioactive
N-cyclopropyl-8-(2,4-dimethoxy-6-methylphenyl)-2,7-dimethyl-N-propylpyrazolo[1,5-a][1,3,5]triazin-4-amine CFAMM00326330 CHEMBL484781 Bioactive
AGN-PC-068CBY CFAMM00326343 CHEMBL474498 Bioactive
AGN-PC-068CC2 CFAMM00326342 CHEMBL474499 Bioactive
AGN-PC-068CC4 CFAMM00326329 CHEMBL474901 Bioactive
AGN-PC-068CC6 CFAMM00326335 CHEMBL484408 Bioactive
AGN-PC-068CBW CFAMM00326320 CHEMBL295563 Bioactive
AGN-PC-073OLH CFAMM00326328 CHEMBL484420 Bioactive
AGN-PC-068CC0 CFAMM00326347 CHEMBL121896 Bioactive
SureCN5872522 CFAMM00326319 CHEMBL515396 Bioactive
AGN-PC-068CC8 CFAMM00326340 CHEMBL521457 Bioactive
AGN-PC-068CCB CFAMM00326327 CHEMBL484421 Bioactive
AGN-PC-068CCA CFAMM00326333 CHEMBL506214 Bioactive
N-[(2R)-butan-2-yl]-8-(2,4-dimethoxy-6-methylphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine CFAMM00326346 CHEMBL120823 Bioactive
N-(cyclopropylmethyl)-3-(2,4-dimethoxyphenyl)-2,5-dimethyl-N-propylpyrazolo[1,5-a]pyrimidin-7-amine
CFAM Mol ID
External ID
Functional Category
Molecule Name
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Dr.
Chen Yuzong Deputy
Director of Center for Computational Science and Engineering All rights reserved.
