CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16783
Family Name Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanophenoxy)-1-phenylpropan-2-yl]-3-methylbutanamide family
No. of Seeds 5 No. of Other Members 0
Family Centroid CFAMM00439352 Functional Category Bioactive
Superfamily Amine oxidase [flavin-containing] A and Amine oxidase [flavin-containing] B Inhibitor (+/-)-2-(4'-butoxyphenyl)thiomorpholin-5-one Superfamily
Class Class 412

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
HIV-1 protease Inhibitor Lopinavir Family 4 25
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Beta-3 adrenergic receptor Ligand Amibegron Family 8 46
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-331440 Family 6 7
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Dipeptidyl peptidase 4 Inhibitor (2-chloro-6-phenoxyphenyl)met... 17 24
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Prothrombin and Tissue-type plasminogen activator inhibitor CH... 10 5
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 1 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
E3 ubiquitin-protein ligase XIAP inhibitor N-METHYLALANYL-3-ME... 3 14
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 6 21
Nitric oxide synthase, inducible and Cytochrome P450 2D6 inhib... 2 1
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 6
Pol polyprotein inhibitor MDL 74538 family 11 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[(2... 10 12
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Motilin receptor ligand SureCN74051 family 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (5Z,8... 4 2
Scytalone dehydratase inhibitor (1R)-2,2-dichloro-1-ethyl-N-[(... 9 1
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Plasmepsin-2 and Cathepsin D inhibitor N-[2-(1,3-benzodioxol-5... 4 0
Scytalone dehydratase inhibitor (2R)-2-cyano-N-[(2R)-1-(2,3-di... 15 0
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Stromelysin-1 and Interstitial collagenase inhibitor (2R)-2-[4... 4 1
Cathepsin K and Cathepsin L1 inhibitor dipeptidyl nitrile, 16c... 1 0
Growth hormone secretagogue receptor type 1 ligand N-benzyl-2-... 5 19
C-C chemokine receptor type 2 ligand (E)-N-[(1S,3R)-3-[[4-(4-m... 1 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00439349 CHEMBL41555 Bioactive 2-cyano-N-[(1S,2R)-1-(2,5-difluorophenoxy)-1-phenylpropan-2-yl]-3-methylbutanamide
CFAMM00439346 CHEMBL40838 Bioactive 2-cyano-N-[(1S,2R)-1-(2-cyanophenoxy)-1-phenylpropan-2-yl]butanamide
CFAMM00439353 CHEMBL417897 Bioactive N-[(1S,2R)-1-(5-chloro-2-cyanophenoxy)-1-phenylpropan-2-yl]-2-cyanobutanamide
CFAMM00439352 CHEMBL418441 Bioactive 2-cyano-N-[(1S,2R)-1-(2-cyanophenoxy)-1-phenylpropan-2-yl]-3-methylbutanamide
CFAMM00439350 CHEMBL418515 Bioactive 2-cyano-N-[(1S,2R)-1-(2-cyanophenoxy)-1-phenylpropan-2-yl]-3,3-dimethylbutanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27043 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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