CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1681
Family Name Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ligand N-[2-[1-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)piperidin-4-yl]ethylcarbamoyl]benzamide family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00161086 Functional Category Bioactive
Superfamily Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor Binder Superfamily 3
Class Class 3406

Cousin Family NamesSeedsMembers
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Ectonucleotide pyrophosphatase/phosphodiesterase family member... 4 10
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 8
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 10
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Histamine H3 receptor ligand 2-methyl-4-[4-(3-pyrrolidin-1-ylp... 4 1
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 4 22
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
5-hydroxytryptamine receptor 1A ligand (3S)-3-[4-(7,9-dioxo-8-... 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 191
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
C-C chemokine receptor type 1 ligand [2-[(2S)-3-(5-chlorospiro... 3 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Potassium voltage-gated channel subfamily H member 2 and C-C c... 2 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 3 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
Histamine H1 receptor ligand SureCN7952197 family 1 0
Histone deacetylase 3 and Histone deacetylase 6 inhibitor (E)-... 1 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 2 0
Putative NP ZINC02127056 Family 4 1
Putative NP ZINC00519603 Family 8 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26197 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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