CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1682
Family Name Cytochrome P450 11B2, mitochondrial and Cytochrome P450 3A4 inhibitor 2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(2-methylpropyl)-1,4-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide family
No. of Seeds 6 No. of Other Members 10
Family Centroid CFAMM00326369 Functional Category Bioactive
Superfamily Cytochrome P450 11B2, mitochondrial and Cytochrome P450 3A4 Binder Superfamily
Class Class 3427

Cousin Family NamesSeedsMembers
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
Histamine H3 receptor Ligand SCH79687 Family 11 29
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 1 2
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 3A4 in... 2 0


External ID

Functional Category

Molecule Name

CFAMM00326370 CHEMBL1209693 Bioactive 2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(2-methoxy-2-methylpropyl)-1,4-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
CFAMM00326360 CHEMBL1208801 Bioactive 2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(cyclopropylmethyl)-1,4-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
CFAMM00326369 CHEMBL1209625 Bioactive 2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(2-methylpropyl)-1,4-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
CFAMM00326365 CHEMBL1209553 Bioactive AGN-PC-088VJN
CFAMM00326374 CHEMBL1209694 Bioactive 2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(propan-2-yloxymethyl)-1,4-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
CFAMM00326364 CHEMBL1209628 Bioactive 2-[(1S)-1-(4-chlorophenyl)ethyl]-4-[(3-methyloxetan-3-yl)methyl]-1,4-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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