CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16869
Family Name Neutrophil elastase inhibitor 4-[(E)-3-[[(2S)-3-methyl-1-oxo-1-[2-[(1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)carbamoyl]pyrrolidin-1-yl]butan-2-yl]amino]-3-oxoprop-1-enyl]benzoic acid family
No. of Seeds 2 No. of Other Members 6
Family Centroid CFAMM00439722 Functional Category Bioactive
Superfamily Proto-oncogene tyrosine-protein kinase Src Inhibitor RU85053 Superfamily
Class Class 923

Cousin Family NamesSeedsMembers
Flovagatran family 12 546
Neutrophil elastase Inhibitor FK-706 Family 8 85
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Delta-type opioid receptor Ligand H-cxp-ala-gly-phe-leu-oh Family 1 8
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-... 10 4
Neutrophil elastase and Chymotrypsin-C inhibitor benzyl N-[6-(... 3 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 9
Neutrophil elastase inhibitor benzyl N-[(2S)-1-[(2S)-2-[[(3S)-... 4 0
Neutrophil elastase inhibitor benzyl N-[(2S)-3-methyl-1-[(2S)-... 2 0
Dipeptidyl peptidase 4 inhibitor (2S,3S)-3-amino-2-[4-(4-fluor... 1 0
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 13 22
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 1 4
Dipeptidyl peptidase 4 inhibitor 3-[2-[(4R,5R)-5-amino-2-oxo-4... 1 4
Neutrophil elastase inhibitor SureCN7273831 family 2 2
Protease inhibitor AC1O54RX family 2 4
Neutrophil elastase inhibitor 3-[[(2S)-3-methyl-1-oxo-1-[2-[(1... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00439715 CHEMBL55912 Bioactive ethyl 4-[(E)-3-[[(2S)-3-methyl-1-oxo-1-[2-[(1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)carbamoyl]pyrrolidin-1-yl]butan-2-yl]amino]-3-oxoprop-1-enyl]benzoate
CFAMM00439722 CHEMBL418117 Bioactive 4-[(E)-3-[[(2S)-3-methyl-1-oxo-1-[2-[(1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)carbamoyl]pyrrolidin-1-yl]butan-2-yl]amino]-3-oxoprop-1-enyl]benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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