CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16896
Family Name Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine deriv. 4b family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00439796 Functional Category Bioactive
Superfamily Muscleblind-like protein 1 and Orexin receptor type 2 Binder Superfamily
Class Class 3969

Cousin Family NamesSeedsMembers
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 11
GDC-0349 family 44 77
Reverse transcriptase Inhibitor Benzothiadiazines Family 4 21
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... 11 18
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M82N fa... 13 0
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M46L fa... 2 7
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Cyclin-dependent kinase 1 inhibitor 4-[[4-(3H-benzimidazol-5-y... 1 0
Cannabinoid receptor 2 ligand 2-tert-butyl-1-(oxan-4-ylmethyl)... 8 2
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Transient receptor potential cation channel subfamily V member... 4 0
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
Phosphatidylinositol 3-kinase regulatory subunit alpha and Pho... 7 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 0
Protein farnesyltransferase alpha subunit and Protein farnesyl... 5 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 1
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-b]pyridazine d... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00439793 CHEMBL419634 Bioactive Imidazo[1,2-a]pyridine deriv. 4e
CFAMM00439796 CHEMBL70808 Bioactive Imidazo[1,2-a]pyridine deriv. 4b
CFAMM00439795 CHEMBL73038 Bioactive Imidazo[1,2-a]pyridine deriv. 4d
CFAMM00439794 CHEMBL72464 Bioactive Imidazo[1,2-a]pyridine deriv. 4a

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26822 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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