CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16899
Family Name Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibitor 2,4-bis anilino pyrimidine deriv. 24 family
No. of Seeds 1 No. of Other Members 3
Family Centroid CFAMM00308167 Functional Category Bioactive
Superfamily Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Binder Superfamily 2
Class Class 153

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Tyrosine-protein kinase JAK2 Inhibitor TG101348 Family 2 4
AP26113 family 16 90
SB1518 family 7 103
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Vascular endothelial growth factor receptor 2 ligand 1-[4-[6-a... 11 13
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Vascular endothelial growth factor receptor 2 ligand urea deri... 2 1
Receptor tyrosine-protein kinase erbB-2 ligand 2-[2-[4-[3-chlo... 4 5
Wee1-like protein kinase and ALK tyrosine kinase receptor liga... 1 9
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Lysine--tRNA ligase and Tyrosine-protein kinase Lyn inhibitor ... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 4
Vascular endothelial growth factor receptor 2 ligand SureCN472... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27432 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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