CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16905
Family Name 72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-[[(2S)-3-cyclohexyl-1-oxo-1-[2-(4-sulfamoylphenyl)ethylamino]propan-2-yl]carbamoyl]-6-phenylhexanoic acid family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00348576 Functional Category Bioactive
Superfamily 72 kDa type IV collagenase and Collagenase 3 Binder Superfamily 2
Class Class 1866

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Cathepsin K Inhibitor Odanacatib Family 33 84
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Neuromedin-K receptor Ligand Senktide Family 15 22
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Thymidylate synthase Inhibitor Sp-876 Family 7 117
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-valp... 8 5
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-3-[... 13 17
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Pol polyprotein inhibitor Lysine Sulfonamide 11t family 1 4
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Disintegrin and metalloproteinase domain-containing protein 17... 6 5
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6368512 f... 23 21
Integrin beta-1 and Integrin alpha-4 inhibitor (3R)-3-[[(2S)-1... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (3R)-3-[[(2S)-1... 3 0
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5686807 f... 7 2
Growth factor receptor-bound protein 2 ligand 2-[(9S,10S,11E,1... 5 14
Pol polyprotein inhibitor Lysine derivative 12 family 6 6
Carbonic anhydrase 12 and Carbonic anhydrase 2 inhibitor AGN-P... 5 0
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2-[2-[... 10 5
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 3 3
Angiotensin-converting enzyme inhibitor (2S)-2-[[(2S)-1-[carbo... 2 5
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Renin and Cathepsin D inhibitor ethyl (4S)-5-cyclohexyl-2,2-di... 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2S)-2-... 2 5
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Carbonic anhydrase 2 inhibitor benzyl 2-[[2-[[(2S)-3-phenyl-2-... 2 9
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
A disintegrin and metalloproteinase with thrombospondin motifs... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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