CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1691
Family Name Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenylethyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-4-pyridin-2-yl-1,3-thiazol-2-amine family
No. of Seeds 5 No. of Other Members 1
Family Centroid CFAMM00326465 Functional Category Bioactive
Superfamily Tyrosine-protein kinase SYK and Neuropeptide Y receptor type 5 Binder Superfamily
Class Class 1642

Cousin Family NamesSeedsMembers
Fumarate reductase flavoprotein subunit Inhibitor Thiabendazol... 3 20
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing... 3 16
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 14 Inhibitor 9-benzyl-6-pheny... 5 33
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Metabotropic glutamate receptor 5 Ligand N-[4-(3-pyridylethyny... 2 10
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(naphthalen-1-yl)-4-neo... 5 78
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Histamine H3 receptor Ligand 2-(1,4'-bipiperidin-1'-yl)thiazol... 2 23
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 2 7
Mitogen-activated protein kinase 14 inhibitor 6-[3-amino-5-(2-... 4 9
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 20
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 2 0
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Neuropeptide Y receptor type 5 and Potassium voltage-gated cha... 2 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
5-hydroxytryptamine receptor 6 ligand 6-chloro-5-[1-(1-methylp... 9 0
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Neuropeptide Y receptor type 5 ligand N-[5-(4,5-dihydro-[1]ben... 8 9
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-[2-[(4-mor... 2 3
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-N-[... 3 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 5-[5-chloro-... 2 18
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Serine/threonine-protein kinase Chk1 inhibitor 2-(1,3-dihydroi... 2 5
Methionine aminopeptidase 2 inhibitor SureCN5376630 family 1 0
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Glucocorticoid receptor ligand 3-(1H-indol-5-yl)-2,2-dimethyl-... 2 7
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Mitogen-activated protein kinase 14 inhibitor 303163-37-3 family 1 2
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Bombesin receptor subtype-3 ligand AGN-PC-07ZCL7 family 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00326466 CHEMBL1209049 Bioactive 2-methyl-1-[(1S,5R)-6-[[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]propan-1-one
CFAMM00326465 CHEMBL1209346 Bioactive N-[[(1S,5R)-3-(1-phenylethyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-4-pyridin-2-yl-1,3-thiazol-2-amine
CFAMM00326464 CHEMBL1209345 Bioactive N-[[(1R,5S)-3-[(3,5-difluorophenyl)methyl]-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-4-pyridin-2-yl-1,3-thiazol-2-amine
CFAMM00326470 CHEMBL1209279 Bioactive N-[[(1R,5S)-3-(2-methylpropyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-4-pyridin-2-yl-1,3-thiazol-2-amine
CFAMM00326468 CHEMBL1209281 Bioactive N-[[(1R,5S)-3-[(3,5-dimethylphenyl)methyl]-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-4-pyridin-2-yl-1,3-thiazol-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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