CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1692
Family Name Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]ethanone family
No. of Seeds 9 No. of Other Members 11
Family Centroid CFAMM00326475 Functional Category Bioactive with Natural Product
Superfamily Tyrosine-protein kinase SYK and Neuropeptide Y receptor type 5 Binder Superfamily
Class Class 1642

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
mRNA of Glucagon receptor Ligand Isis 325568 Family 1 3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing... 3 16
DNA primase Inhibitor Bay 57-1293 Family 1 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Cathepsin B and Cathepsin K Inhibitor L-006235-1 Family 19 75
Metabotropic glutamate receptor 5 Ligand N-[4-(3-pyridylethyny... 2 10
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Mitogen-activated protein kinase 11 and Mitogen-activated prot... 10 31
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 1 26
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Histone deacetylase 1 and Histone deacetylase 2 inhibitor AGN-... 2 5
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Neuropeptide Y receptor type 5 and Potassium voltage-gated cha... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Protease and Capsid scaffolding protein inhibitor AC1LAC7K family 2 5
Cellular tumor antigen p53 inhibitor CHEMBL1395891 family 1 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 9 1
Inosine-5'-monophosphate dehydrogenase and Nuclear receptor RO... 2 9
Coagulation factor X and Prothrombin inhibitor (2S)-2-(benzyls... 4 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 13 37
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Cyclin-dependent kinase 5 and G1/S-specific cyclin-E1 inhibito... 1 1
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(4-phenyl-1,3-t... 3 4
Cathepsin K and Cathepsin S inhibitor (1R,2R)-2-[4-(1,3-benzot... 1 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
Cathepsin K and Cathepsin L1 inhibitor (2R)-N-(cyanomethyl)-4-... 2 1
Metabotropic glutamate receptor 5 ligand 5-methyl-N-(4-methyl-... 1 2
Cholinesterase and Acetylcholinesterase inhibitor 3-[ethyl-[3-... 6 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
P2X purinoceptor 7 inhibitor SureCN110930 family 2 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Serine/threonine-protein kinase Chk1 inhibitor 2-(1,3-dihydroi... 2 5
Serine/threonine-protein kinase Chk1 inhibitor 2-indazol-1-yl-... 4 5
Orexin receptor type 2 and Orexin receptor type 1 ligand 6-ami... 3 1
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 6 1
Glucocorticoid receptor ligand 3-[1-(3-chloro-4-fluorophenyl)i... 2 0
Glucocorticoid receptor ligand 3-(1H-indol-5-yl)-2,2-dimethyl-... 2 7
MAP kinase-activated protein kinase 2 inhibitor 2-[(4,4-dimeth... 11 11
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Platelet-activating factor receptor ligand 1,8-dimethyl-5-[4-(... 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HL8Q family 4 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 5 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Methionine aminopeptidase and Methionine aminopeptidase 1 inhi... 3 7
Probable G-protein coupled receptor 142 ligand (2S)-3-phenyl-N... 2 2
Histone deacetylase 1 inhibitor SureCN1066177 family 1 1
Tyrosyl-DNA phosphodiesterase 1 and ATP-dependent molecular ch... 1 0
Methionine aminopeptidase 1 inhibitor N-[5-[2-oxo-2-[4-(2-pyri... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00326476 CHEMBL1209100 Bioactive pyridin-3-yl-[(1R,5S)-6-[[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]methanone
CFAMM00326494 CHEMBL1209159 Bioactive 2-phenyl-1-[(1R,5S)-6-[[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]propan-1-one
CFAMM00326483 CHEMBL1209215 Bioactive 2-methyl-3-phenyl-1-[(1R,5S)-6-[[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]butan-1-one
CFAMM00326475 CHEMBL1209101 Bioactive 2-phenyl-1-[(1R,5S)-6-[[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]ethanone
CFAMM00326482 CHEMBL1209216 Bioactive [(1S,2S)-2-phenylcyclopropyl]-[(1R,5S)-6-[[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]methanone
CFAMM00326480 CHEMBL1209052 Bioactive (3-fluorophenyl)-[(1R,5S)-6-[[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]methanone
CFAMM00326487 CHEMBL1209160 Bioactive (1-phenylcyclopropyl)-[(1S,5R)-6-[[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]methanone
CFAMM00326479 CHEMBL1209053 Bioactive (3,5-difluorophenyl)-[(1R,5S)-6-[[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]methanone
CFAMM00326486 CHEMBL1209161 Bioactive 3-phenyl-1-[(1R,5S)-6-[[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]propan-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46031 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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