CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16932
Family Name Substance-P receptor ligand AGN-PC-00FIT5 family
No. of Seeds 3 No. of Other Members 11
Family Centroid CFAMM00439901 Functional Category Bioactive with Natural Product
Superfamily Substance-P receptor and Leukotriene B4 receptor 1 Binder Superfamily
Class Class 2449

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Indeglitazar family 3 39
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 391
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 0
Glucocorticoid receptor and Progesterone receptor ligand AGN-P... 3 3
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Cholinesterase and Acetylcholinesterase inhibitor 5-hydroxy-7-... 5 19
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Growth hormone secretagogue receptor type 1 ligand N-[(1R)-2-(... 3 2
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
C-C chemokine receptor type 2 ligand (E)-1-[4-[2-hydroxy-1-[4-... 2 2
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-methoxypheny... 1 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Rho-associated protein kinase 2 and RAC-alpha serine/threonine... 1 2
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Transient receptor potential cation channel subfamily V member... 3 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(6aR... 1 0
Caspase-3 and Caspase-7 inhibitor (2S)-N-[(3S)-2-hydroxy-5-oxo... 4 1
ATP-binding cassette sub-family G member 2 inhibitor 5-[(4-bro... 1 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 0
Indoles Metabolite 4-[N-(p-Coumaroyl)serotonin-4''-yl]-N-ferul... 3 0
NP N-(1h-indol-6-yl)-3-(4-methoxy-1h-indol-1-yl)propanamide Fa... 2 0
Putative NP ZINC40309500 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00439910 CHEMBL42295 Bioactive AGN-PC-0D60KV
CFAMM00439901 CHEMBL42259 Bioactive AGN-PC-00FIT5
CFAMM00439907 CHEMBL43044 Bioactive SureCN7088172

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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