CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16957
Family Name Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha and Geranylgeranyl transferase type-1 subunit beta inhibitor N-(1-adamantyl)-4-[[3-[(4-cyanophenyl)methyl]imidazol-4-yl]methyl]piperazine-1-carboxamide family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00215590 Functional Category Bioactive
Superfamily Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha and Protein farnesyltransferase subunit beta Binder Superfamily
Class Class 177

Cousin Family NamesSeedsMembers
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Farnesyltransferase beta subunit, putative Inhibitor BMS214662... 11 65
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
Histamine H3 receptor Ligand SCH79687 Family 11 29
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 2 1
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Metabotropic glutamate receptor 5 ligand [(E)-(1,2-dicyclohexy... 1 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 0
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 10 0
Dipeptidyl peptidase 4 inhibitor 7-(aminomethyl)-6-(2-chloroph... 2 5
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Macrophage colony-stimulating factor 1 receptor and Receptor-t... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27511 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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