CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1696
Family Name Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family
No. of Seeds 3 No. of Other Members 11
Family Centroid CFAMM00326431 Functional Category Bioactive with Natural Product
Superfamily SB1518 Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Histamine H1 receptor Ligand Mepyramine Family 5 65
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
AP26113 family 16 90
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Metabotropic glutamate receptor 1 Ligand 4-(cyclohexyloxy)quin... 1 4
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-07YOWS family 4 6
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Cathepsin S and Cathepsin K inhibitor AGN-PC-07YOWR family 1 0
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Corticotropin-releasing factor receptor 1 ligand 3,6-diethyl-5... 7 8
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Dihydrofolate reductase inhibitor 3-(2,4-diamino-6-methylquina... 2 1
Dihydrofolate reductase inhibitor 7-(5-chloro-2-ethoxyphenyl)-... 2 1
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Xanthine dehydrogenase/oxidase inhibitor 4-[[4-(2-aminopyrimid... 3 16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Beta-secretase 1 and Beta-secretase 2 inhibitor 7-fluoro-3-(5-... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Transient receptor potential cation channel subfamily V member... 2 4
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
TRAF2 and NCK-interacting protein kinase and Serine/threonine-... 2 2
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Xanthine dehydrogenase/oxidase inhibitor 5-(2-amino-4-oxo-1H-p... 8 30
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Transient receptor potential cation channel subfamily V member... 2 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Adenosine receptor A1 and Adenosine receptor A2a ligand 7-meth... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2
Dihydrofolate reductase inhibitor 5-[3-(3-methoxy-5-morpholin-... 2 0
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 3 35
Heat shock protein HSP 90-alpha inhibitor 4-[2-Chloro-6-(4,4,4... 2 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00326545 CHEMBL1210690 Bioactive AGN-PC-088VZM

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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