CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17
Family Name Proto-oncogene tyrosine-protein kinase Src inhibitor N-(2,4-dichloro-5-methoxyphenyl)-8-methoxy-7-(2-methoxyethoxy)-5,10-dihydropyrimido[4,5-b]quinolin-4-amine family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00305955 Functional Category Bioactive
Superfamily Cellular tumor antigen p53 and ALK tyrosine kinase receptor Binder Superfamily
Class Class 386

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
Tivozanib family 4 6
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Platelet-derived growth factor receptor beta and Platelet-deri... 2 19
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Receptor-type tyrosine-protein kinase FLT3 ligand 2-(6,7-dimet... 3 2
Vascular endothelial growth factor receptor 2 and Vascular end... 3 3
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS94Q ... 6 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
cGMP-specific 3',5'-cyclic phosphodiesterase and cAMP-specific... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00305956 CHEMBL102000 Bioactive N-(2,4-dichloro-5-methoxyphenyl)-7,8-dimethoxy-5,10-dihydropyrimido[4,5-b]quinolin-4-amine
CFAMM00305955 CHEMBL100172 Bioactive N-(2,4-dichloro-5-methoxyphenyl)-8-methoxy-7-(2-methoxyethoxy)-5,10-dihydropyrimido[4,5-b]quinolin-4-amine
CFAMM00305954 CHEMBL100551 Bioactive N-(2,4-dichloro-5-methoxyphenyl)-7-methoxy-8-(2-methoxyethoxy)-5,10-dihydropyrimido[4,5-b]quinolin-4-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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