CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17029
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1D ligand N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)butane-1,4-diamine family
No. of Seeds 10 No. of Other Members 8
Family Centroid CFAMM00440236 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1D Binder Superfamily 3
Class Class 2933

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Adenosine receptor A2a Ligand Dexefaroxan Family 11 46
Alpha-2 adrenergic receptor Ligand Idazoxan Family 6 26
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 1 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 1 0


External ID

Functional Category

Molecule Name

CFAMM00440222 CHEMBL88283 Bioactive N-[(8-methoxy-3,4-dihydro-2H-chromen-2-yl)methyl]-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
CFAMM00440228 CHEMBL91123 Bioactive N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-(2,3,4,5-tetrahydropyridin-6-yl)propane-1,3-diamine
CFAMM00440234 CHEMBL88240 Bioactive Alniditan
CFAMM00440233 CHEMBL90405 Bioactive N-[(6-fluoro-3,4-dihydro-2H-chromen-2-yl)methyl]-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
CFAMM00440226 CHEMBL88784 Bioactive N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)pentane-1,5-diamine
CFAMM00440231 CHEMBL89878 Bioactive N-[(7-ethyl-3,4-dihydro-2H-chromen-2-yl)methyl]-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
CFAMM00440237 CHEMBL88676 Bioactive SureCN717888
CFAMM00440236 CHEMBL431211 Bioactive N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)butane-1,4-diamine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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