CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1706
Family Name Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C-tert-butyl-N-hydroxycarbonimidoyl]phenyl]-1-methylpyrrole-2-carbonitrile family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00326594 Functional Category Bioactive
Superfamily Progesterone receptor and Androgen receptor Binder Superfamily
Class Class 3431

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 3-fluoro-5-(2-methylq... 3 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 3
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YYL... 1 3
Progesterone receptor ligand AGN-PC-07CHIE family 7 10
Progesterone receptor and Androgen receptor ligand AGN-PC-04V9... 2 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
D(4) dopamine receptor and D(1A) dopamine receptor ligand 2-[[... 5 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
Progesterone receptor ligand N-[4-(5-cyano-1-methylpyrrol-2-yl... 6 6
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 1
5-hydroxytryptamine receptor 1D ligand AGN-PC-01NTBS family 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Thromboxane-A synthase inhibitor AGN-PC-07BYVF family 1 0
Cytochrome P450 2C19 inhibitor CHEMBL1449918 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00326603 CHEMBL1934442 Bioactive 1-benzyl-4-(4-cyanophenyl)-2,5-dimethylpyrrole-3-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27746 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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