CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17069
Family Name CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family
No. of Seeds 2 No. of Other Members 8
Family Centroid CFAMM00440416 Functional Category Bioactive
Superfamily Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-yl)-1-methyl-1h-indole Superfamily
Class Class 656

Cousin Family NamesSeedsMembers
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Cytochrome P450 3A4 Inhibitor 3-(5-((methylthio)methyl)furan-2... 4 14
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Coagulation factor X and Prothrombin Inhibitor BMS-344577 Family 13 12
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Potassium voltage-gated channel subfamily H member 2 and Neuro... 3 4
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 11
Lanosterol synthase inhibitor (4-bromophenyl)-[6-[6-[methyl(pr... 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 9 12
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Ferritin light chain and Ras-related protein Rab-9A inhibitor ... 1 11
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Cellular tumor antigen p53 and Lethal(3)malignant brain tumor-... 1 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Histamine H3 receptor ligand SureCN2784306 family 5 3
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Retinoic acid receptor RXR-alpha ligand 6-[(3-butoxy-5,5,8,8-t... 2 2
Proteinase-activated receptor 1 ligand (3R,3aR,4S,5R,6S,7aS)-5... 2 3
Beta-3 adrenergic receptor ligand 6-[4-[2-[[(2S)-3-[(3,3-dimet... 6 7
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 3
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 2 2
Sodium-dependent serotonin transporter inhibitor SureCN5477150... 4 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 2 7
Metabotropic glutamate receptor 5 ligand 3-fluoro-5-(5-pyridin... 1 0
Tyrosine-protein kinase JAK3 and Activated CDC42 kinase 1 inhi... 4 1
Coagulation factor X inhibitor 3-Oxybenzamide 15 family 1 1
NP N-(2-(3,4-dimethoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinami... 6 1
NP N-(2-(2-methoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinamide F... 9 0
carboxamide NP ZINC15729349 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00440416 CHEMBL435110 Bioactive AGN-PC-075IHL

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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