CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1709
Family Name Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-N-methyl-4-phenyl-1-(pyrimidine-2-carbonyl)pyrrolidine-3-carboxamide family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00326618 Functional Category Bioactive
Superfamily Histone deacetylase 6 Inhibitor ACY-1215 Superfamily
Class Class 144

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Prothrombin Inhibitor Dabigatran Family 7 182
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
C-C chemokine receptor type 5 Ligand Vicriviroc Family 4 31
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Translocator protein Inhibitor Emapunil Family 7 89
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PHA848125 family 13 138
JAK Inhibitor Momelotinib Family 33 83
PF-4136309 family 16 27
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Class II cytokine receptor Ligand IL-10 Family 7 45
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
C-C chemokine receptor type 5 ligand [3-[2-[(3aS,6aR)-5-(4,6-d... 3 40
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
C-C chemokine receptor type 5 ligand AC1LA25C family 3 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(3,4-di... 3 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 18
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Histamine H3 receptor ligand SureCN2878688 family 8 1
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 6 0
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Substance-P receptor ligand Netupitant family 5 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 4 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-[2-(trif... 1 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(tria... 1 0
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
C-C chemokine receptor type 5 ligand N-[3-[4-[3-cyclohexyl-5-(... 5 4
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Transient receptor potential cation channel subfamily V member... 1 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Collagenase 3 inhibitor MMP-13 Inhibitor family 1 1
Egl nine homolog 1 inhibitor 2-[(1,6-diphenylimidazo[4,5-c]pyr... 1 5
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Beta-lactamase inhibitor CHEMBL1497312 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00326619 CHEMBL429798 Bioactive (3R,4S)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-N-methyl-4-phenyl-1-(pyrimidine-4-carbonyl)pyrrolidine-3-carboxamide
CFAMM00326618 CHEMBL393745 Bioactive (3R,4S)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-N-methyl-4-phenyl-1-(pyrimidine-2-carbonyl)pyrrolidine-3-carboxamide
CFAMM00326613 CHEMBL1209319 Bioactive N-[2-[4-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-2-cyclohexylethyl]-N-propan-2-ylpyrimidine-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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