CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17090
Family Name Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluorophenyl)sulfonyl-3-[5-fluoro-1-[(3-methoxyphenyl)methyl]-3-methylindol-7-yl]prop-2-enamide family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00440501 Functional Category Bioactive
Superfamily Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Superfamily
Class Class 82

Cousin Family NamesSeedsMembers
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Serine/threonine-protein kinase PLK1 Inhibitor HMN-214 Family 3 58
Apricoxib family 8 77
Indeglitazar family 3 39
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methyls... 3 12
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
5-hydroxytryptamine receptor 6 ligand N-[3-[[(2R)-1-methylpyrr... 6 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Cannabinoid receptor 2 ligand AGN-PC-09M5M9 family 1 0
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 15
Progesterone receptor and Androgen receptor ligand AGN-PC-04QD... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
Collagenase 3 and A disintegrin and metalloproteinase with thr... 5 6
5-hydroxytryptamine receptor 6 ligand SureCN5253197 family 4 2
5-hydroxytryptamine receptor 6 ligand 9-(4-methoxyphenyl)sulfo... 1 0
Peroxisome proliferator-activated receptor gamma ligand NSI fa... 5 3
5-hydroxytryptamine receptor 6 ligand 1-(2-bromo-4-methoxyphen... 2 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Cysteinyl leukotriene receptor 1 ligand 1-[[4-[(2-chlorophenyl... 4 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 2
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
Oxytocin receptor and Vasopressin V1a receptor ligand 4-methox... 9 8
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-(1-methyl-4... 14 12
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,5-dichlo... 2 9
Prostaglandin E2 receptor EP3 subtype ligand N-(benzenesulfony... 17 15
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-[4-(4-chlor... 7 0
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 1 0
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 14 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00440499 CHEMBL43770 Bioactive 3-[3-[(4-fluorophenyl)methyl]-5-[(4-methoxyphenyl)sulfonylamino]indol-1-yl]propanoic acid
CFAMM00440498 CHEMBL480029 Bioactive (E)-3-[5-fluoro-1-[(3-methoxyphenyl)methyl]-3-methylindol-7-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamide
CFAMM00440501 CHEMBL584904 Bioactive (E)-N-(3,4-difluorophenyl)sulfonyl-3-[5-fluoro-1-[(3-methoxyphenyl)methyl]-3-methylindol-7-yl]prop-2-enamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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