CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17114
Family Name Bifunctional dihydrofolate reductase-thymidylate synthase and Dihydrofolate reductase inhibitor 5-[(4-butoxy-3,5-dipropylphenyl)methyl]pyrimidine-2,4-diamine family
No. of Seeds 1 No. of Other Members 3
Family Centroid CFAMM00092668 Functional Category Bioactive
Superfamily Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexyl-2-(pyrimidin-2-yloxy)phenol Superfamily
Class Class 1208

Cousin Family NamesSeedsMembers
Endothelin B receptor and Endothelin-1 receptor ligand pyrimid... 22 180
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Histamine H1 receptor Ligand Mepyramine Family 5 65
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
SB1518 family 7 103
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Peptide deformylase, mitochondrial Inhibitor Brodimoprim-4,6-d... 9 1
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 2 3
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
Deoxycytidine kinase inhibitor AGN-PC-07Z9C8 family 5 3
Deoxycytidine kinase inhibitor AGN-PC-07Z9GO family 10 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 1 7
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 4 2
Endothelin-1 receptor ligand AGN-PC-00GZJQ family 12 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 6
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Dihydrofolate reductase inhibitor (E)-3-[5-[(2,4-diaminopyrimi... 3 2
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 8
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Dihydrofolate reductase inhibitor 2-bromo-N-[4-[4-[(2,4-diamin... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Xanthine dehydrogenase/oxidase inhibitor 4-[[4-(2-aminopyrimid... 3 16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Beta-secretase 1 and Beta-secretase 2 inhibitor 7-fluoro-3-(5-... 2 7
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
Transient receptor potential cation channel subfamily V member... 2 4
Xanthine dehydrogenase/oxidase inhibitor 5-(2-amino-4-oxo-1H-p... 8 30
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 1 0
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 12
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 21
P2X purinoceptor 3 and P2X purinoceptor 2 inhibitor 2-[[4-amin... 10 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[3,4-di... 2 0
Glucose-dependent insulinotropic receptor ligand tert-butyl 4-... 1 1
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45931 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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