CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17146
Family Name Vascular endothelial growth factor receptor 2 ligand pyrimidine, 3 family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00440765 Functional Category Bioactive
Superfamily Epidermal growth factor receptor and Signal transducer Binder Superfamily
Class Class 1031

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Tyrosine kinase Inhibitor PKI166 Family 17 198
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Metabotropic glutamate receptor 1 Ligand 4-(cyclohexyloxy)quin... 1 4
Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Wee1-like protein kinase and ALK tyrosine kinase receptor liga... 1 9
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Aurora kinase A inhibitor Bisanilinopyrimidine, 6i family 1 0
Aurora kinase A inhibitor 4-[[4-(2-chloroanilino)pyrimidin-2-y... 1 0
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Transient receptor potential cation channel subfamily V member... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Ephrin type-A receptor 3 and Tyrosine-protein kinase Fgr ligan... 1 3
Tyrosine-protein kinase TXK and Tyrosine-protein kinase Lyn in... 1 1
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-071H3F fa... 3 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-04WVYY family 1 0
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
cAMP-dependent protein kinase catalytic subunit beta and cAMP-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00440766 CHEMBL93302 Bioactive PD153035 Analog 38
CFAMM00440765 CHEMBL444138 Bioactive pyrimidine, 3

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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