CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17165
Family Name Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methoxy-2-methyl-1H-indol-3-yl)acetyl]amino]-7-(5-naphthalen-2-yl-1H-imidazol-2-yl)heptanamide family
No. of Seeds 1 No. of Other Members 2
Family Centroid CFAMM00440843 Functional Category Bioactive
Superfamily TGF-beta receptor type-1 and Telomerase reverse transcriptase Binder Superfamily
Class Class 1456

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Epidermal Growth Factor family 111 209
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Eluxadoline family 4 85
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Renin Inhibitor Enalkiren Family 56 44
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Type-1 angiotensin II receptor ligand N-[2-(3-methoxyphenyl)et... 2 0
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Scavenger receptor class B member 1 ligand 5-[9-[3-(4,6-dimeth... 7 3
5-hydroxytryptamine receptor 1D ligand N-[4-[[5-[3-[2-(dimethy... 4 16
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 8 13
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 0
5-hydroxytryptamine receptor 6 ligand 2-[(2Z)-2-[3-[(3-methoxy... 1 11
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 1 3
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00440843 CHEMBL445506 Bioactive (7S)-N-hydroxy-7-[[2-(5-methoxy-2-methyl-1H-indol-3-yl)acetyl]amino]-7-(5-naphthalen-2-yl-1H-imidazol-2-yl)heptanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26822 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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